Journal article
Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report
Journal of neurosurgery. Spine, Vol.21(4), pp.618-622
10/2014
DOI: 10.3171/2014.5.SPINE13992
PMID: 25002238
Abstract
Over the last decade, human cell transplantation and neural stem cell trials have examined the feasibility and safety of these potential therapies for treatment of a variety of neurological disorders. However, significant safety concerns have surrounded these trials due to the possibility of ectopic, uncontrolled cellular growth and tumor formation. The authors present the case of an 18-year-old woman who sustained a complete spinal cord injury at T10–11. Three years after injury, she remained paraplegic and underwent olfactory mucosal cell implantation at the site of injury. She developed back pain 8 years later, and imaging revealed an intramedullary spinal cord mass at the site of cell implantation, which required resection. Intraoperative findings revealed an expanded spinal cord with a multicystic mass containing large amounts of thick mucus-like material. Histological examination and immunohistochemical staining revealed that the mass was composed mostly of cysts lined by respiratory epithelium, submucosal glands with goblet cells, and intervening nerve twigs. This is the first report of a human spinal cord mass complicating spinal cord cell transplantation and neural stem cell therapy. Given the prolonged time to presentation, safety monitoring of all patients with cell transplantation and neural stem cell implantation should be maintained for many years.
Details
- Title: Subtitle
- Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report
- Creators
- Brian J Dlouhy - Departments of 1Neurosurgery andOlatilewa Awe - Departments of 1Neurosurgery andRajesh C Rao - Departments of 2Ophthalmology and Visual Sciences and, 3Pathology, University of Michigan Medical School, Ann Arbor, MichiganPatricia A Kirby - 4Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa; andPatrick W Hitchon - Departments of 1Neurosurgery and
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery. Spine, Vol.21(4), pp.618-622
- DOI
- 10.3171/2014.5.SPINE13992
- PMID
- 25002238
- NLM abbreviation
- J Neurosurg Spine
- ISSN
- 1547-5654
- eISSN
- 1547-5646
- Publisher
- American Association of Neurological Surgeons
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984040383802771
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