Autoimmune Disorders Affecting the Larynx: Review of Laryngoscopic Findings and Approach to Multidisciplinary Management

Aditya Kotla; Emma Thayer; Gatr-Alnada Gheriani; Abigail E Moore; C Blake Simpson; Matthew R Hoffman

doi:10.1177/00034894251408704

Back

Autoimmune Disorders Affecting the Larynx: Review of Laryngoscopic Findings and Approach to Multidisciplinary Management

Journal article

Peer reviewed

Autoimmune Disorders Affecting the Larynx: Review of Laryngoscopic Findings and Approach to Multidisciplinary Management

Aditya Kotla, Emma Thayer, Gatr-Alnada Gheriani, Abigail E Moore, C Blake Simpson and Matthew R Hoffman

Annals of otology, rhinology & laryngology, PMID 407300

01/26/2026

DOI: 10.1177/00034894251408704

PMID: 41587910

View Online

Abstract

The prevalence of autoimmune diseases has been increasing globally. Many disorders have manifestations within the larynx and patients may present initially to the otolaryngologist with breathing, voice, or swallow concerns. This review focuses on the laryngotracheal manifestations of various autoimmune diseases and associated laryngoscopic abnormalities that commonly occur with autoimmune disease, including infraglottic stenosis, bamboo nodules, cricoarytenoid joint ankylosis, supraglottic stenosis, and multilevel airway stenosis. Commonly implicated autoimmune disorders including granulomatosis with polyangiitis (GPA), ANCA-negative GPA, rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus (SLE), pemphigus vulgaris, ankylosing spondylitis, sarcoidosis, relapsing polychondritis, and IgG4-related disease are reviewed with emphasis on clinical presentation, typical laryngoscopic findings, diagnostic criteria, and therapeutic options specific to the larynx. A systematic multi-disciplinary approach between the otolaryngologist and rheumatologist is presented. Prompt identification of a laryngeal abnormality as being potentially related to autoimmune disease and direct communication with rheumatology colleagues can offer patients medical treatment options in addition to procedural intervention and may offer long-term benefits to laryngeal function and overall disease-specific health.

autoimmune disorders

larynx

subglottic stenosis

supraglottic stenosis

laryngoscopic abnormalities

cricoarytenoid joint ankyloses

Details

Title: Subtitle: Autoimmune Disorders Affecting the Larynx: Review of Laryngoscopic Findings and Approach to Multidisciplinary Management
Creators: Aditya Kotla - University of Iowa
Emma Thayer - University of Iowa
Gatr-Alnada Gheriani - University of Iowa, Internal Medicine
Abigail E Moore - University of Iowa
C Blake Simpson - University of Alabama at Birmingham
Matthew R Hoffman - University of Iowa
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, PMID 407300
DOI: 10.1177/00034894251408704
PMID: 41587910
NLM abbreviation: Ann Otol Rhinol Laryngol
ISSN: 0003-4894
eISSN: 1943-572X
Publisher: Sage
Language: English
Electronic publication date: 01/26/2026
Academic Unit: Communication Sciences and Disorders; Stead Family Department of Pediatrics; Otolaryngology; Internal Medicine
Record Identifier: 9985132081502771

Metrics

4 Record Views

See more details