Journal article
Autoimmune biomarkers in glaucoma patients
Current opinion in pharmacology, Vol.13(1), pp.90-97
02/2013
DOI: 10.1016/j.coph.2012.09.005
PMID: 23031798
Abstract
There is growing evidence showing an autoimmune involvement in the pathogenesis of glaucoma, and that alterations in natural occurring autoantibody levels play a key role. The upregulation of autoantibodies can be associated with fatal conditions, but several studies demonstrate that natural autoantibodies entail also protective characteristics and influence the protein expression of neuroretinal cells. A disbalance of natural occurring autoantibodies may shift the physiological equilibrium of protective immunity leading to a predisposition for developing glaucoma. This article highlights recent advances in understanding of autoimmune mechanisms in the pathogenesis of glaucoma.
Details
- Title: Subtitle
- Autoimmune biomarkers in glaucoma patients
- Creators
- Oliver W Gramlich - Experimental Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, GermanyKatharina BellNadine von Thun Und Hohenstein-BlaulCorina WildingSabine BeckNorbert PfeifferFranz H Grus
- Resource Type
- Journal article
- Publication Details
- Current opinion in pharmacology, Vol.13(1), pp.90-97
- Publisher
- England
- DOI
- 10.1016/j.coph.2012.09.005
- PMID
- 23031798
- ISSN
- 1471-4892
- eISSN
- 1471-4973
- Grant note
- name: DFG (Deutsche Forschungsgemeinschaft); name: Forschungsschwerpunkt Translationale Neurowissenschaften (FTN); DOI: 10.13039/501100004346, name: Stiftung Rheinland-Pfalz für Innovation; name: Deutsche Ophthalmologische Gesellschaft (DOG)
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070274702771
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