Journal article
Autoimmune retinopathy in the absence of cancer
American journal of ophthalmology, Vol.123(5), pp.607-618
05/1997
DOI: 10.1016/s0002-9394(14)71073-6
PMID: 9152066
Abstract
To report the clinical and immunologic features of two patients with progressive retinal degeneration and circulating antiretinal antibodies without systemic malignancy. Two patients were followed up for 5 to 7 years. Comprehensive medical and ophthalmic examinations and visual function testing included manual perimetry and standardized electroretinography. Patient sera were tested for antiretinal antibodies by Western blot and immunoperoxidase indirect cytochemistry techniques. Two patients had family history of autoimmune disease. Each had severe monocular visual loss with photopsia, a ring scotoma, and abnormal electroretinogram despite a normal-appearing ocular fundus. One had a flat electroretinogram; the other had inner retina dysfunction, with selective b wave loss and abnormal oscillatory potentials. Both patients' sera had antiretinal antibodies that specifically labeled the inner plexiform layer of donor retina by indirect immunoperoxidase testing. Neither had any sign of cancer. In two patients without systemic malignancy, the symptoms, perimetric findings, and normal fundus appearance resembled cancer associated retinopathy. Electroretinography and antibody findings indicating dysfunction of the inner retina are distinct from those of cancer-associated retinopathy. These two cases raise the possibility of an autoimmune mechanism for retinal degeneration that is not cancer associated. Further study is necessary to determine the role of antiretinal antibodies in these patients.
Details
- Title: Subtitle
- Autoimmune retinopathy in the absence of cancer
- Creators
- Jane B Mizener - Department of Ophthalmology, University of Iowa, Iowa City 52242, USAAlan E KimuraGrazyna AdamusCharles E Thirkill - University of California, DavisJames A GoekenRandy H Kardon
- Resource Type
- Journal article
- Publication Details
- American journal of ophthalmology, Vol.123(5), pp.607-618
- DOI
- 10.1016/s0002-9394(14)71073-6
- PMID
- 9152066
- NLM abbreviation
- Am J Ophthalmol
- ISSN
- 0002-9394
- eISSN
- 1879-1891
- Publisher
- United States
- Grant note
- EY10316 / NEI NIH HHS
- Language
- English
- Date published
- 05/1997
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979968202771
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