Journal article
Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle
The American journal of pathology, Vol.119(3), pp.448-455
1985
PMCID: PMC1888015
PMID: 4014434
Abstract
Lymphocytes sensitized in vitro to syngenic microvascular smooth muscle and transferred to syngeneic recipients produced in vivo microvessel vasculitis characterized by mononuclear cells which adhered to endothelium, infiltrated the vessel wall, and formed a perivascular cuff. A granulomatous type of vascular inflammation was seen in 20% of the affected recipients in which the vessel smooth muscle appeared to be preferentially attacked. These lesions bear a striking resemblance to certain human vasculitides, and the model provides an important means of studying vasculitis as well as general cellular autoimmune disease mechanisms.
Details
- Title: Subtitle
- Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle
- Creators
- M. N HART - Univ. Iowa, coll. medicine, Iowa City IA 52242, United StatesS. K TASSELL - Univ. Iowa, coll. medicine, Iowa City IA 52242, United StatesK. L SADEWASSER - Univ. Iowa, coll. medicine, Iowa City IA 52242, United StatesR. L SCHELPER - Univ. Iowa, coll. medicine, Iowa City IA 52242, United StatesS. A MOORE - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The American journal of pathology, Vol.119(3), pp.448-455
- Publisher
- American Society for Investigative Pathology; Bethesda, MD
- PMID
- 4014434
- PMCID
- PMC1888015
- ISSN
- 0002-9440
- eISSN
- 1525-2191
- Language
- English
- Date published
- 1985
- Academic Unit
- Pathology
- Record Identifier
- 9984047607202771
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