Journal article
Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review
Journal of personalized medicine, Vol.14(4), p.435
04/01/2024
DOI: 10.3390/jpm14040435
PMCID: PMC11051445
PMID: 38673062
Abstract
Orthostatic intolerance is a broad term that represents a spectrum of dysautonomic disorders, including postural orthostatic tachycardia syndrome (POTS) and orthostatic hypotension (OH), as manifestations of severe autonomic failure. While the etiology of orthostatic intolerance has not yet fully been uncovered, it has been associated with multiple underlying pathological processes, including peripheral neuropathy, altered renin-aldosterone levels, hypovolemia, and autoimmune processes. Studies have implicated adrenergic, cholinergic, and angiotensin II type I autoantibodies in the pathogenesis of orthostatic intolerance. Several case series have demonstrated that immunomodulation therapy resulted in favorable outcomes, improving autonomic symptoms in POTS and OH. In this review, we highlight the contemporary literature detailing the association of autoimmunity with POTS and OH.
Details
- Title: Subtitle
- Autoimmunity in Syndromes of Orthostatic Intolerance: An Updated Review
- Creators
- Clarissa Pena - University of ToledoAbdelmoniem Moustafa - University of ToledoAbdel-Rhman Mohamed - University of ToledoBlair Grubb - University of Toledo
- Resource Type
- Journal article
- Publication Details
- Journal of personalized medicine, Vol.14(4), p.435
- DOI
- 10.3390/jpm14040435
- PMID
- 38673062
- PMCID
- PMC11051445
- NLM abbreviation
- J Pers Med
- ISSN
- 2075-4426
- eISSN
- 2075-4426
- Publisher
- Mdpi
- Number of pages
- 14
- Language
- English
- Date published
- 04/01/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984843250402771
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