Autoinflammatory Skin Disorders: The Inflammasomme in Focus

Prajwal Gurung; Thirumala-Devi Kanneganti

doi:10.1016/j.molmed.2016.05.003

Back

Autoinflammatory Skin Disorders: The Inflammasomme in Focus

Journal article

Open access

Peer reviewed

Autoinflammatory Skin Disorders: The Inflammasomme in Focus

Prajwal Gurung and Thirumala-Devi Kanneganti

Trends in molecular medicine, Vol.22(7), pp.545-564

07/2016

DOI: 10.1016/j.molmed.2016.05.003

PMCID: PMC4925313

PMID: 27267764

Files and links (1)

url

https://doi.org/10.1016/j.molmed.2016.05.003View

Published (Version of record) Open Access

Abstract

Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders.

Cryopyrin-Associated Periodic Syndromes - immunology

Familial Mediterranean Fever - pathology

Animals

Humans

Inflammasomes - immunology

Interleukin-1 - immunology

Cryopyrin-Associated Periodic Syndromes - pathology

Familial Mediterranean Fever - immunology

Skin - pathology

Disease Models, Animal

Skin - immunology

Details

Title: Subtitle: Autoinflammatory Skin Disorders: The Inflammasomme in Focus
Creators: Prajwal Gurung - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Thirumala-Devi Kanneganti - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: thirumala-devi.kanneganti@stjude.org
Resource Type: Journal article
Publication Details: Trends in molecular medicine, Vol.22(7), pp.545-564
DOI: 10.1016/j.molmed.2016.05.003
PMID: 27267764
PMCID: PMC4925313
ISSN: 1471-4914
eISSN: 1471-499X
Grant note: R01 AI101935 / NIAID NIH HHS R01 AR056296 / NIAMS NIH HHS R37 AI101935 / NIAID NIH HHS R01 CA163507 / NCI NIH HHS R01 AI124346 / NIAID NIH HHS
Language: English
Date published: 07/2016
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9984094597802771

Metrics

19 Record Views

48 Times Cited - Web of Science

See more details