Autoinflammatory bone diseases

Sara M Stern; Polly J Ferguson

doi:10.1016/j.rdc.2013.05.002

Back

Journal article

Open access

Peer reviewed

Autoinflammatory bone diseases

Sara M Stern and Polly J Ferguson

Rheumatic diseases clinics of North America, Vol.39(4), pp.735-749

11/2013

DOI: 10.1016/j.rdc.2013.05.002

PMCID: PMC3823499

PMID: 24182852

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3823499View

Open Access

Abstract

Autoinflammatory bone disease is a new branch of autoinflammatory diseases caused by seemingly unprovoked activation of the innate immune system leading to an osseous inflammatory process. The inflammatory bone lesions in these disorders are characterized by chronic inflammation that is typically culture negative with no demonstrable organism on histopathology. The most common autoinflammatory bone diseases in childhood include chronic nonbacterial osteomyelitis (CNO), synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, Majeed syndrome, deficiency of interleukin-1 receptor antagonist, and cherubism. In this article, the authors focus on CNO and summarize the distinct genetic autoinflammatory bone syndromes.

Acne Vulgaris - immunology

Humans

Anemia, Dyserythropoietic, Congenital - diagnosis

Cherubism - diagnosis

Osteomyelitis - therapy

Synovitis - therapy

Acquired Hyperostosis Syndrome - therapy

Synovitis - immunology

Acne Vulgaris - therapy

Synovitis - diagnosis

Hereditary Autoinflammatory Diseases - therapy

Acquired Hyperostosis Syndrome - diagnosis

Hyperostosis - therapy

Anemia, Dyserythropoietic, Congenital - therapy

Bone Diseases - therapy

Cherubism - therapy

Interleukin 1 Receptor Antagonist Protein - immunology

Cherubism - immunology

Hereditary Autoinflammatory Diseases - immunology

Inflammation

Hereditary Autoinflammatory Diseases - diagnosis

Bone Diseases - immunology

Osteomyelitis - immunology

Bone Diseases - diagnosis

Syndrome

Hyperostosis - diagnosis

Anemia, Dyserythropoietic, Congenital - immunology

Osteitis - diagnosis

Osteitis - immunology

Osteomyelitis - diagnosis

Acne Vulgaris - diagnosis

Hyperostosis - immunology

Osteitis - therapy

Acquired Hyperostosis Syndrome - immunology

Chronic Disease

Details

Title: Subtitle: Autoinflammatory bone diseases
Creators: Sara M Stern - Division of Immunology, Rheumatology, and Allergy, Department of Pediatrics, University of Utah, PO Box 581289, Salt Lake City, UT 84158, USA. Electronic address: Sara.Stern@hsc.utah.edu
Polly J Ferguson
Resource Type: Journal article
Publication Details: Rheumatic diseases clinics of North America, Vol.39(4), pp.735-749
DOI: 10.1016/j.rdc.2013.05.002
PMID: 24182852
PMCID: PMC3823499
NLM abbreviation: Rheum Dis Clin North Am
ISSN: 0889-857X
eISSN: 1558-3163
Publisher: United States
Grant note: 1R01AR059703-01A1 / NIAMS NIH HHS R01 AR059703 / NIAMS NIH HHS
Language: English
Date published: 11/2013
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
Record Identifier: 9984065739502771

Metrics

37 Record Views

87 Times Cited - Web of Science

See more details