Journal article
Autoinhibitory domains: modular effectors of cellular regulation
Annual review of cell and developmental biology, Vol.18(1), pp.421-462
2002
DOI: 10.1146/annurev.cellbio.18.031502.133614
PMID: 12142282
Abstract
Autoinhibitory domains are regions of proteins that negatively regulate the function of other domains via intramolecular interactions. Autoinhibition is a potent regulatory mechanism that provides tight "on-site" repression. The discovery of autoinhibition generates valuable clues to how a protein is regulated within a biological context. Mechanisms that counteract the autoinhibition, including proteolysis, post-translational modifications, as well as addition of proteins or small molecules in trans, often represent central regulatory pathways. In this review, we document the diversity of instances in which autoinhibition acts in cell regulation. Seven well-characterized examples (e.g., sigma(70), Ets-1, ERM, SNARE and WASP proteins, SREBP, Src) are covered in detail. Over thirty additional examples are listed. We present experimental approaches to characterize autoinhibitory domains and discuss the implications of this widespread phenomenon for biological regulation in both the normal and diseased states.
Details
- Title: Subtitle
- Autoinhibitory domains: modular effectors of cellular regulation
- Creators
- Miles A Pufall - Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City 84112-5550, USA. miles.pufall@hci.utah.eduBarbara J Graves
- Resource Type
- Journal article
- Publication Details
- Annual review of cell and developmental biology, Vol.18(1), pp.421-462
- Publisher
- United States
- DOI
- 10.1146/annurev.cellbio.18.031502.133614
- PMID
- 12142282
- ISSN
- 1081-0706
- eISSN
- 1530-8995
- Grant note
- R01 GM38663 / NIGMS NIH HHS GM08537 / NIGMS NIH HHS R01 GM038663 / NIGMS NIH HHS CA93247 / NCI NIH HHS
- Language
- English
- Date published
- 2002
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9984025250102771
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