Journal article
Autologous stem cell therapy for inherited and acquired retinal disease
Regenerative medicine, Vol.13(1), pp.89-96
01/2018
DOI: 10.2217/rme-2017-0089
PMCID: PMC6123878
PMID: 29360008
Abstract
The mammalian retina, derived from neural ectoderm, has little regenerative potential. For conditions where irreversible retinal pigment epithelium or photoreceptor cell loss occurs, advanced techniques are required to restore vision. Inherited retinal dystrophies and some acquired conditions, such as age-related macular degeneration, have a similar end result of photoreceptor cell death leading to debilitating vision loss. These diseases stand to benefit from future regenerative medicine as dietary recommendations and current pharmacologic therapy only seek to prevent further disease progression. Cell-based strategies, such as autologously derived induced pluripotent stem cells, have come a long way in overcoming previous technical and ethical concerns. Clinical trials for such techniques are already underway. These trials and the preceding preclinical studies will be discussed in the context of retinal disease.
Details
- Title: Subtitle
- Autologous stem cell therapy for inherited and acquired retinal disease
- Creators
- Mary Ben L Apatoff - Department of Ophthalmology, Columbia University, New York, NY 10032, USAJesse D Sengillo - College of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USAEugenia C White - Department of Ophthalmology, Columbia University, New York, NY 10032, USAMathieu F Bakhoum - Department of Ophthalmology, Columbia University, New York, NY 10032, USAAlexander G Bassuk - Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USAVinit B Mahajan - Department of Ophthalmology, Palo Alto Veterans Administration, Palo Alto, CA 94304, USAStephen H Tsang - Institute of Human Nutrition, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA
- Resource Type
- Journal article
- Publication Details
- Regenerative medicine, Vol.13(1), pp.89-96
- Publisher
- England
- DOI
- 10.2217/rme-2017-0089
- PMID
- 29360008
- PMCID
- PMC6123878
- ISSN
- 1746-0751
- eISSN
- 1746-076X
- Grant note
- R01 EY018213 / NEI NIH HHS\nR01 EY026682 / NEI NIH HHS\nP30 CA013696 / NCI NIH HHS\nR01 EY024698 / NEI NIH HHS\nP30 EY019007 / NEI NIH HHS\nR21 AG050437 / NIA NIH HHS
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984070631302771
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