Journal article
Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images
Biomedical Optics Express, Vol.2(8), pp.2403-2416
2011
DOI: 10.1364/BOE.2.002403
PMCID: PMC3149538
PMID: 21833377
Abstract
The 3-D spectral-domain optical coherence tomography (SD-OCT) images of the retina often do not reflect the true shape of the retina and are distorted differently along the x and y axes. In this paper, we propose a novel technique that uses thin-plate splines in two stages to estimate and correct the distinct axial artifacts in SD-OCT images. The method was quantitatively validated using nine pairs of OCT scans obtained with orthogonal fast-scanning axes, where a segmented surface was compared after both datasets had been corrected. The mean unsigned difference computed between the locations of this artifact-corrected surface after the single-spline and dual-spline correction was 23.36 ± 4.04 μ m and 5.94 ± 1.09 μ m, respectively, and showed a significant difference ( p < 0.001 from two-tailed paired t -test). The method was also validated using depth maps constructed from stereo fundus photographs of the optic nerve head, which were compared to the flattened top surface from the OCT datasets. Significant differences ( p < 0.001) were noted between the artifact-corrected datasets and the original datasets, where the mean unsigned differences computed over 30 optic-nerve-head-centered scans (in normalized units) were 0.134 ± 0.035 and 0.302 ± 0.134, respectively.
Details
- Title: Subtitle
- Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images
- Creators
- Bhavna Antony - Dept. of Electrical and Computer Engineering, The University of Iowa, Iowa City, IowaMichael D Abràmoff - U.S. Dept. of Veterans Affairs, Iowa City, IowaLi Tang - Dept. of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IowaWishal D Ramdas - Erasmus Medical Center, Depts. of Ophthalmology and Epidemiology, Rotterdam, TheJohannes R Vingerling - Erasmus Medical Center, Depts. of Ophthalmology and Epidemiology, Rotterdam, TheNomdo M Jansonius - University Medical Center Groningen, University of Groningen, TheKyungmoo Lee - Dept. of Electrical and Computer Engineering, The University of Iowa, Iowa City, IowaYoung H Kwon - Dept. of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IowaMilan Sonka - Dept. of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IowaMona K Garvin - U.S. Dept. of Veterans Affairs, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Biomedical Optics Express, Vol.2(8), pp.2403-2416
- DOI
- 10.1364/BOE.2.002403
- PMID
- 21833377
- PMCID
- PMC3149538
- NLM abbreviation
- Biomed Opt Express
- ISSN
- 2156-7085
- eISSN
- 2156-7085
- Publisher
- Optical Society of America
- Grant note
- NEI EY017066; R01 EY018853; R01 EY019112 / National Institutes of Health Department of Veterans Affairs
- Language
- English
- Date published
- 2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983805900902771
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