Journal article
Automated Objective Scoring of Histologically Apparent Cartilage Degeneration Using a Custom Image Analysis Program
Journal of orthopaedic research, Vol.27(4), pp.522-528
04/2009
DOI: 10.1002/jor.20779
PMCID: PMC3682491
PMID: 18972361
Abstract
Histologic assessment of cartilage degradation has traditionally involved semiquantitative techniques, the most commonly utilized being the Mankin scale. Such assessments depend on human observer subjectivity, and thus have drawn criticism on the basis of associated inter- and intraobserver variability. We report a newly developed computational image analysis procedure for fully automated and fully objective assessment of the Mankin scale. Image processing routines were developed in a widely used programming environment (Matlab®) to analyze cartilage degradation. One hundred and twenty-five histology images incorporating a wide range of degradation features were analyzed by the algorithm and by seven observers experienced in cartilage histologic assessment. Based on random effects linear statistical models, the computer program performed well, showing a correlation of 0.88 between its Mankin scores and latent (average of human observers’) image scores. Regarding the four subcomponents of the Mankin scale, computer program correlations with observer scores were best for surface defect and proteoglycan depletion, but less favorable for cellularity and tidemark invasion. While limitations exist with image processing techniques, the new algorithm provides an objective and automated method for analyzing cartilage histology sections, consistent with human observer grading.
Details
- Title: Subtitle
- Automated Objective Scoring of Histologically Apparent Cartilage Degeneration Using a Custom Image Analysis Program
- Creators
- S. Farshid Moussavi-Harami - Department of Orthopaedics and Rehabilitation, 2181 Westlawn Building, University of Iowa, Iowa City, Iowa 52242-1100Douglas R Pedersen - Department of Orthopaedics and Rehabilitation, 2181 Westlawn Building, University of Iowa, Iowa City, Iowa 52242-1100James A Martin - Department of Biomedical Engineering, Orthopaedic Biomechanics Laboratory, University of Iowa, Iowa City, IowaStephen L Hillis - Center for Research in the Implementation of Innovative Strategies in Practice (CRIISP), Department of Veterans Affairs (VA), Iowa City Medical Center, Iowa City, IowaThomas D Brown - Department of Orthopaedics and Rehabilitation, 2181 Westlawn Building, University of Iowa, Iowa City, Iowa 52242-1100
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.27(4), pp.522-528
- DOI
- 10.1002/jor.20779
- PMID
- 18972361
- PMCID
- PMC3682491
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Grant note
- P50 AR048939 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS P50 AR055533 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Language
- English
- Date published
- 04/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040233602771
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