Journal article
Automated detection of malarial retinopathy-associated retinal hemorrhages
Investigative ophthalmology & visual science, Vol.53(10), pp.6582-6588
09/25/2012
DOI: 10.1167/iovs.12-10191
PMCID: PMC3460387
PMID: 22915035
Abstract
To develop an automated method for the detection of retinal hemorrhages on color fundus images to characterize malarial retinopathy, which may help in the assessment of patients with cerebral malaria. A fundus image dataset from 14 patients (200 fundus images, with an average of 14 images per patient) previously diagnosed with malarial retinopathy was examined. We developed a pattern recognition-based algorithm, which extracted features from image watershed regions called splats (tobogganing). A reference standard was obtained by manual segmentation of hemorrhages, which assigned a label to each splat. The splat features with the associated splat label were used to train a linear k-nearest neighbor classifier that learnt the color properties of hemorrhages and identified the splats belonging to hemorrhages in a test dataset. In a crossover design experiment, data from 12 patients were used for training and data from two patients were used for testing, with 14 different permutations; and the derived sensitivity and specificity values were averaged. The experiment resulted in hemorrhage detection sensitivities in terms of splats as 80.83%, and in terms of lesions as 84.84%. The splat-based specificity was 96.67%, whereas for the lesion-based analysis, an average of three false positives was obtained per image. The area under the receiver operating characteristic curve was reported as 0.9148 for splat-based, and as 0.9030 for lesion-based analysis. The method provides an automated means of detecting retinal hemorrhages associated with malarial retinopathy. The results matched well with the reference standard. With further development, this technique may provide automated assistance for screening and quantification of malarial retinopathy.
Details
- Title: Subtitle
- Automated detection of malarial retinopathy-associated retinal hemorrhages
- Creators
- Vinayak S Joshi - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USARichard J MaudeJoseph M ReinhardtLi TangMona K GarvinAbdullah Abu SayeedAniruddha GhoseMahtab Uddin HassanMichael D Abràmoff
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.53(10), pp.6582-6588
- Publisher
- United States
- DOI
- 10.1167/iovs.12-10191
- PMID
- 22915035
- PMCID
- PMC3460387
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Grant note
- R01 EB004640 / NIBIB NIH HHS EY017066 / NEI NIH HHS R01 EY017066 / NEI NIH HHS Wellcome Trust EB004640 / NIBIB NIH HHS 077166/Z/05/Z / Wellcome Trust 089275 / Wellcome Trust
- Language
- English
- Date published
- 09/25/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9983806368602771
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