Automated quantification of volumetric optic disc swelling in papilledema using spectral-domain optical coherence tomography

Jui-Kai Wang; Randy H Kardon; Mark J Kupersmith; Mona K Garvin

doi:10.1167/iovs.12-9438

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Automated quantification of volumetric optic disc swelling in papilledema using spectral-domain optical coherence tomography

Journal article

Open access

Peer reviewed

Automated quantification of volumetric optic disc swelling in papilledema using spectral-domain optical coherence tomography

Jui-Kai Wang, Randy H Kardon, Mark J Kupersmith and Mona K Garvin

Investigative ophthalmology & visual science, Vol.53(7), pp.4069-4075

06/29/2012

DOI: 10.1167/iovs.12-9438

PMCID: PMC3392074

PMID: 22599584

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https://doi.org/10.1167/iovs.12-9438View

Published (Version of record) Open Access

Abstract

To develop an automated method for the quantification of volumetric optic disc swelling in papilledema subjects using spectral-domain optical coherence tomography (SD-OCT) and to determine the extent that such volumetric measurements correlate with Frisén scale grades (from fundus photographs) and two-dimensional (2-D) peripapillary retinal nerve fiber layer (RNFL) and total retinal (TR) thickness measurements from SD-OCT. A custom image-analysis algorithm was developed to obtain peripapillary circular RNFL thickness, TR thickness, and TR volume measurements from SD-OCT volumes of subjects with papilledema. In addition, peripapillary RNFL thickness measures from the commercially available Zeiss SD-OCT machine were obtained. Expert Frisén scale grades were independently obtained from corresponding fundus photographs. In 71 SD-OCT scans, the mean (± standard deviation) resulting TR volumes for Frisén scale 0 to scale 4 were 11.36 ± 0.56, 12.53 ± 1.21, 14.42 ± 2.11, 17.48 ± 2.63, and 21.81 ± 3.16 mm(3), respectively. The Spearman's rank correlation coefficient was 0.737. Using 55 eyes with valid Zeiss RNFL measurements, Pearson's correlation coefficient (r) between the TR volume and the custom algorithm's TR thickness, the custom algorithm's RNFL thickness, and Zeiss' RNFL thickness was 0.980, 0.929, and 0.946, respectively. Between Zeiss' RNFL and the custom algorithm's RNFL, and the study's TR thickness, r was 0.901 and 0.961, respectively. Volumetric measurements of the degree of disc swelling in subjects with papilledema can be obtained from SD-OCT volumes, with the mean volume appearing to be roughly linearly related to the Frisén scale grade. Using such an approach can provide a more continuous, objective, and robust means for assessing the degree of disc swelling compared with presently available approaches.

Nerve Fibers - pathology

Automation

Reproducibility of Results

Humans

Middle Aged

Male

Equipment Design

Retinal Ganglion Cells - pathology

Photography

Young Adult

Tomography, Optical Coherence - instrumentation

Adult

Female

Papilledema - diagnosis

Retrospective Studies

Optic Disk - pathology

Details

Title: Subtitle: Automated quantification of volumetric optic disc swelling in papilledema using spectral-domain optical coherence tomography
Creators: Jui-Kai Wang - Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, USA
Randy H Kardon
Mark J Kupersmith
Mona K Garvin
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.53(7), pp.4069-4075
DOI: 10.1167/iovs.12-9438
PMID: 22599584
PMCID: PMC3392074
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: IK2 RX000728 / RRD VA R009040554 / PHS HHS R01 EY018853 / NEI NIH HHS
Language: English
Date published: 06/29/2012
Academic Unit: Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980057302771

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