Journal article
Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface
Biomechanics and modeling in mechanobiology, Vol.16(2), pp.583-596
04/2017
DOI: 10.1007/s10237-016-0838-6
PMCID: PMC5352464
PMID: 27704229
Abstract
We propose a method to construct three-dimensional airway geometric models based on airway skeletons, or centerlines (CLs). Given a CT-segmented airway skeleton and surface, the proposed CL-based method automatically constructs subject-specific models that contain anatomical information regarding branches, include bifurcations and trifurcations, and extend from the trachea to terminal bronchioles. The resulting model can be anatomically realistic with the assistance of an image-based surface; alternatively a model with an idealized skeleton and/or branch diameters is also possible. This method systematically identifies and classifies trifurcations to successfully construct the models, which also provides the number and type of trifurcations for the analysis of the airways from an anatomical point of view. We applied this method to 16 normal and 16 severe asthmatic subjects using their computed tomography images. The average distance between the surface of the model and the image-based surface was 11 % of the average voxel size of the image. The four most frequent locations of trifurcations were the left upper division bronchus, left lower lobar bronchus, right upper lobar bronchus, and right intermediate bronchus. The proposed method automatically constructed accurate subject-specific three-dimensional airway geometric models that contain anatomical information regarding branches using airway skeleton, diameters, and image-based surface geometry. The proposed method can construct (i) geometry automatically for population-based studies, (ii) trifurcations to retain the original airway topology, (iii) geometry that can be used for automatic generation of computational fluid dynamics meshes, and (iv) geometry based only on a skeleton and diameters for idealized branches.
Details
- Title: Subtitle
- Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface
- Creators
- Shinjiro Miyawaki - CH2M, 1100 NE Circle Blvd., Suite 300, Corvallis, OR, 97330, USAMerryn H Tawhai - Auckland Bioengineering Institute, University of Auckland, Auckland, New ZealandEric A Hoffman - The Department of Biomedical Engineering, Medicine, and Radiology, University of Iowa, Iowa City, IA, 52242, USASally E Wenzel - The Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USAChing-Long Lin - IIHR-Hydroscience and Engineering and the Department of Mechanical and Industrial Engineering, University of Iowa, 3131 Seamans Center, Iowa City, IA, 52242, USA. ching-long-lin@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Biomechanics and modeling in mechanobiology, Vol.16(2), pp.583-596
- DOI
- 10.1007/s10237-016-0838-6
- PMID
- 27704229
- PMCID
- PMC5352464
- NLM abbreviation
- Biomech Model Mechanobiol
- ISSN
- 1617-7959
- eISSN
- 1617-7940
- Publisher
- Germany
- Grant note
- U01 HL114494 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL094315 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS S10 RR022421 / NCRR NIH HHS P30 DK054759 / NIDDK NIH HHS
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984051768902771
Metrics
33 Record Views