Autonomic Innervation Evaluation in Cardiac Disease

Adriana Xavier de Brito; Adriana Glavam; Ana Inês Bronchtein; Paulo Henrique Rosado-De-castro

doi:10.36660/ijcs.20200171

Back

Autonomic Innervation Evaluation in Cardiac Disease

Journal article

Open access

Peer reviewed

Autonomic Innervation Evaluation in Cardiac Disease

Adriana Xavier de Brito, Adriana Glavam, Ana Inês Bronchtein and Paulo Henrique Rosado-De-castro

International journal of cardiovascular sciences, Vol.34(6), pp.702-713

12/01/2021

DOI: 10.36660/ijcs.20200171

Files and links (1)

url

https://doi.org/10.36660/ijcs.20200171View

Published (Version of record) Open Access

Abstract

Cardiovascular diseases are among the leading causes of mortality and morbidity in the world. In different cardiac diseases, the neuronal function of the heart is impaired. Nevertheless, the development of a simple method to assess the autonomic effects on the heart and/or autonomic dysfunction is a challenge. The evaluation of autonomic innervation in cardiac diseases has helped to improve the knowledge of the pathophysiology of these conditions, as well as to provide information on their prognosis. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are currently the only imaging methods that allow in vivo assessment of cardiac innervation. The majority of SPECT and PET radiotracers evaluate sympathetic neuronal integrity using presynaptic imaging agents that are either labeled as endogenous transmitters or analogues. Postsynaptic imaging agents have also been developed to study sympathetic neuronal integrity, as well as tracers to investigate the parasympathetic nervous system. These methods may be used to analyze the innervation of the heart and allow for early detection of abnormalities caused by, for example, ischemia, heart failure, cardiomyopathies, cardiotoxicity, and arrhythmogenic disorders. This review provides an overview of cardiac innervation evaluation and their application in the assessment of heart disease.

Heart Failure

Autonomic Denervation

Autonomic Nervous System

Diagnostic, IImaging

Myocardial Ischemia

Details

Title: Subtitle: Autonomic Innervation Evaluation in Cardiac Disease
Creators: Adriana Xavier de Brito - Rede D'Or São Luiz, Rio de Janeiro, Brazil
Adriana Glavam - Universidade do Estado do Rio de Janeiro
Ana Inês Bronchtein - Universidade do Estado do Rio de Janeiro
Paulo Henrique Rosado-De-castro - Universidade do Estado do Rio de Janeiro
Resource Type: Journal article
Publication Details: International journal of cardiovascular sciences, Vol.34(6), pp.702-713
DOI: 10.36660/ijcs.20200171
ISSN: 2359-4802
eISSN: 2359-5647
Number of pages: 12
Language: English
Date published: 12/01/2021
Academic Unit: Radiology
Record Identifier: 9985143124502771

Metrics

1 Record Views