Journal article
Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases
European journal of heart failure, Vol.25(5), pp.642-656
05/2023
DOI: 10.1002/ejhf.2819
PMCID: PMC10989193
PMID: 36907827
Abstract
The importance of chemoreflex function for cardiovascular health is increasingly recognized in clinical practice. The physiological function of the chemoreflex is to constantly adjust ventilation and circulatory control to match respiratory gases to metabolism. This is achieved in a highly integrated fashion with the baroreflex and the ergoreflex. The functionality of chemoreceptors is altered in cardiovascular diseases, causing unstable ventilation and apnoeas and promoting sympathovagal imbalance, and it is associated with arrhythmias and fatal cardiorespiratory events. In the last few years, opportunities to desensitize hyperactive chemoreceptors have emerged as potential options for treatment of hypertension and heart failure. This review summarizes up to date evidence of chemoreflex physiology/pathophysiology, highlighting the clinical significance of chemoreflex dysfunction, and lists the latest proof of concept studies based on modulation of the chemoreflex as a novel target in cardiovascular diseases.
Details
- Title: Subtitle
- Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases
- Creators
- Alberto Giannoni - Sant'Anna School of Advanced StudiesChiara Borrelli - Fondazione Toscana Gabriele MonasterioFrancesco Gentile - Sant'Anna School of Advanced StudiesPaolo Sciarrone - Fondazione Toscana Gabriele MonasterioJens Spießhöfer - Sant'Anna School of Advanced StudiesMassimo Piepoli - Guglielmo da Saliceto HospitalGeorge B Richerson - University of IowaJohn S Floras - Mount Sinai HospitalAndrew Js Coats - University of WarwickShahrokh Javaheri - Bethesda North HospitalMichele Emdin - Sant'Anna School of Advanced StudiesClaudio Passino - Sant'Anna School of Advanced Studies
- Resource Type
- Journal article
- Publication Details
- European journal of heart failure, Vol.25(5), pp.642-656
- DOI
- 10.1002/ejhf.2819
- PMID
- 36907827
- PMCID
- PMC10989193
- eISSN
- 1879-0844
- Language
- English
- Electronic publication date
- 03/12/2023
- Date published
- 05/2023
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984378330602771
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