Journal article
Autonomic cardiovascular modulation
IEEE engineering in medicine and biology magazine, Vol.28(6), pp.79-85
11/2009
DOI: 10.1109/MEMB.2009.934620
PMID: 19914892
Abstract
We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one.
Details
- Title: Subtitle
- Autonomic cardiovascular modulation
- Creators
- Eleonora Tobaldini - Laboratorio di Modellistica di Sistemi Complessi, Dipartimento di Tecnologie per Salute, Istituto Ortopedico Galeazzi, Università degli Studi di Milano, Via R. Galeazzi 4, 20161 Milan, ItalyNicola MontanoShun-Guang WeiZhi-Hua ZhangJoseph FrancisRobert M WeissKarina R CasaliRobert B FelderAlberto Porta
- Resource Type
- Journal article
- Publication Details
- IEEE engineering in medicine and biology magazine, Vol.28(6), pp.79-85
- Publisher
- United States
- DOI
- 10.1109/MEMB.2009.934620
- PMID
- 19914892
- ISSN
- 0739-5175
- eISSN
- 1937-4186
- Grant note
- R01 HL-063915 / NHLBI NIH HHS R01 HL063915 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065386502771
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