Journal article
Autonomic changes in Huntington’s disease correlate with altered central autonomic network connectivity
Brain communications, Vol.4(5), fcac253
10/07/2022
DOI: 10.1093/braincomms/fcac253
PMCID: PMC9617256
PMID: 36324870
Abstract
Autonomic dysfunction has been described in patients with Huntington’s disease, but it is unclear if these changes in autonomic tone are related to the central autonomic network. We performed a pilot study to investigate the relationship between the integrity of the central autonomic network and peripheral manifestiations of autonomic dysfunction in premanifest Huntington’s disease. We recruited male participants with pre-motor-manifest Huntington’s disease and a comparison group consisting of healthy, male participants of approximately the same age. As this was a pilot study, only males were included to reduce confounding. Participants underwent a resting-state functional magnetic resonance imaging study to quantify functional connectivity within the central autonomic network, as well as a resting 3-lead ECG to measure heart rate variability with a particular focus on the parasympathetic time-domain measures of root mean square of successive differences between normal heartbeats. The pre-motor-manifest Huntington’s disease participants had significantly decreased root mean square of successive differences between normal heartbeats values compared with the healthy comparison group. The pre-motor-manifest Huntington’s disease group had significantly lower functional connectivity within the central autonomic network, which was positively correlated with root mean square of successive differences between normal heartbeats. Patients with pre-motor-manifest Huntington’s disease have reduced functional connectivity within the central autonomic network, which is significantly associated with observed changes in autonomic function.
Schultz
et al
. report that autonomic dysfunction in patients with presymptomatic Huntington’s disease was associated with decreased functional connectivity within the Central Autonomic Network. These results provide insight into the underlying pathology of autonomic dysfunction in Huntington’s disease and its possible use as a marker for disease progression.
Graphical abstract
Details
- Title: Subtitle
- Autonomic changes in Huntington’s disease correlate with altered central autonomic network connectivity
- Creators
- Jordan L Schultz - Roy J. and Lucille A. Carver College of MedicineAmanda E Heinzerling - Roy J. and Lucille A. Carver College of MedicineAlivia N Brinker - Roy J. and Lucille A. Carver College of MedicineLyndsay A Harshman - Roy J. and Lucille A. Carver College of MedicineVincent A Magnotta - University of IowaJohn A Kamholz - Roy J. and Lucille A. Carver College of MedicineAaron D Boes - Roy J. and Lucille A. Carver College of MedicinePeg C Nopoulos - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Brain communications, Vol.4(5), fcac253
- DOI
- 10.1093/braincomms/fcac253
- PMID
- 36324870
- PMCID
- PMC9617256
- NLM abbreviation
- Brain Commun
- ISSN
- 2632-1297
- eISSN
- 2632-1297
- Publisher
- Oxford University Press
- Grant note
- ;
- Language
- English
- Date published
- 10/07/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Radiation Oncology; Pharmacy Practice and Science; Neurology (Pediatrics)
- Record Identifier
- 9984307658502771
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