Journal article
Autonomic regulation of the immune system in cardiovascular diseases
Advances in physiology education, Vol.41(4), pp.578-593
12/01/2017
DOI: 10.1152/advan.00061.2017
PMCID: PMC6105770
PMID: 29138216
Abstract
The autonomic nervous system is a powerful regulator of circulatory adjustments to acute hemodynamic stresses. Here we focus on new concepts that emphasize the chronic influence of the sympathetic and parasympathetic systems on cardiovascular pathology. The autonomic neurohumoral system can dramatically influence morbidity and mortality from cardiovascular disease through newly discovered influences on the innate and adaptive immune systems. Specifically, the end-organ damage in heart failure or hypertension may be worsened or alleviated by pro- or anti-inflammatory pathways of the immune system, respectively, that are activated through neurohumoral transmitters. These concepts provide a major new perspective on potentially life-saving therapeutic interventions in the deadliest of diseases.
Details
- Title: Subtitle
- Autonomic regulation of the immune system in cardiovascular diseases
- Creators
- François M Abboud - Departments of Internal Medicine and Molecular Physiology and Biophysics, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa francois-abboud@uiowa.eduMadhu V Singh - Departments of Internal Medicine and Molecular Physiology and Biophysics, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Advances in physiology education, Vol.41(4), pp.578-593
- Publisher
- United States
- DOI
- 10.1152/advan.00061.2017
- PMID
- 29138216
- PMCID
- PMC6105770
- ISSN
- 1043-4046
- eISSN
- 1522-1229
- Grant note
- P01 HL014388 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/01/2017
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025305702771
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