Autophagy during common bacterial and viral infections of children

Charles Grose

doi:10.1097/INF.0b013e3181e77f43

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Autophagy during common bacterial and viral infections of children

Journal article

Open access

Peer reviewed

Autophagy during common bacterial and viral infections of children

Charles Grose

The Pediatric infectious disease journal, Vol.29(11), pp.1040-1042

11/2010

DOI: 10.1097/INF.0b013e3181e77f43

PMCID: PMC2964450

PMID: 20562672

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Abstract

Autophagy is a well-known survival mechanism of the cell. Autophagosomes remove excessive proteins and thereby maintain homeostasis within the cell. Autophagy is now recognized as a component of both innate and adaptive immune responses to bacterial and viral pathogens common to children. These pathogens include Streptococcus, tuberculosis, as well as hepatitis and herpes viruses. Varicella-zoster virus infection provides an excellent example of autophagy in humans, because abundant autophagosomes are easily detected in the skin vesicles of both varicella and zoster. Engineered herpes viruses, which elicit autophagy responses, are being used currently in clinical therapeutic trials against brain cancer. Furthermore, defective autophagy of bacteria may explain in part the pathogenesis of Crohn disease. However, at present, there is no single screening diagnostic assay by which to measure autophagy, as a means to investigate an etiologic role in children with an as yet undefined immunodeficiency. Instead, translational researchers are measuring individual components of the cellular autophagy pathway in both humans and animal models, to correlate autophagy responses with severity of infection. Autophagy certainly will remain a subject of immunology investigations in children in the coming decade.

Phagosomes - microbiology

Phagosomes - virology

Virus Diseases - immunology

Humans

Virus Diseases - virology

Host-Pathogen Interactions - immunology

Autophagy - immunology

Phagosomes - immunology

Animals

Bacterial Infections - immunology

Bacterial Infections - pathology

Virus Diseases - pathology

Child

Bacterial Infections - microbiology

Details

Title: Subtitle: Autophagy during common bacterial and viral infections of children
Creators: Charles Grose - Virology Division, Children's Hospital, University of Iowa, Iowa City, IA 52242, USA. charles-grose@uiowa.edu
Resource Type: Journal article
Publication Details: The Pediatric infectious disease journal, Vol.29(11), pp.1040-1042
DOI: 10.1097/INF.0b013e3181e77f43
PMID: 20562672
PMCID: PMC2964450
NLM abbreviation: Pediatr Infect Dis J
ISSN: 0891-3668
eISSN: 1532-0987
Grant note: R01 AI089716 / NIAID NIH HHS R01 AI022795 / NIAID NIH HHS
Language: English
Date published: 11/2010
Academic Unit: Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093231002771

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