Autophagy following heat stress: the role of aging and protein nitration

Jamie M Swanlund; Kevin C Kregel; Terry D Oberley

doi:10.4161/auto.6768

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Autophagy following heat stress: the role of aging and protein nitration

Journal article

Open access

Peer reviewed

Autophagy following heat stress: the role of aging and protein nitration

Jamie M Swanlund, Kevin C Kregel and Terry D Oberley

Autophagy, Vol.4(7), pp.936-939

10/2008

DOI: 10.4161/auto.6768

PMCID: PMC2577755

PMID: 18758235

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Abstract

Stress can originate from a variety of sources (e.g., physical, chemical, etc.,) and cause protein denaturation, DNA damage and possibly death. In an effort to prevent such deleterious consequences, most organisms possess one or more ways to counteract or even prevent the harmful effect(s) from a given stressor. Such compensation by an organism is known as a stress response; this involves inhibition of housekeeping genes and subsequent activation of genes associated with the stress response. One of the most widely studied groups of stress response genes is a family of molecular chaperones known as heat shock proteins (HSPs). Work from our laboratory agrees with many other studies showing an age-related decline in stress-induced synthesis of HSPs. A decline in the availability and/or function of HSPs with age can lead to accumulation of damaged proteins, which in turn damages cells. Recently, our laboratory found a significant increase in mitochondrial damage as well as evidence of increased autophagy in rat hepatocytes following heat stress. These results, along with findings of increased protein nitration with age, suggest a major role for reactive nitrogen species (RNS) in both the decline in HSP induction and increased hepatocyte pathology observed in old rats following heat stress.

Aging - metabolism

Animals

Autophagy

Heat Stress Disorders - metabolism

Heat Stress Disorders - pathology

Heat-Shock Proteins - biosynthesis

Heat-Shock Proteins - metabolism

Hepatocytes - metabolism

Hepatocytes - pathology

Rats

Reactive Nitrogen Species - metabolism

Details

Title: Subtitle: Autophagy following heat stress: the role of aging and protein nitration
Creators: Jamie M Swanlund - Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Kevin C Kregel
Terry D Oberley
Resource Type: Journal article
Publication Details: Autophagy, Vol.4(7), pp.936-939
DOI: 10.4161/auto.6768
PMID: 18758235
PMCID: PMC2577755
NLM abbreviation: Autophagy
ISSN: 1554-8627
eISSN: 1554-8635
Grant note: R01 AG012350-09A1 / NIA NIH HHS
Language: English
Date published: 10/2008
Academic Unit: Radiation Oncology; Provost Office Administration; Health, Sport, and Human Physiology
Record Identifier: 9984213451102771

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35 Times Cited - Web of Science