Journal article
Auxiliary subunits: essential components of the voltage-gated calcium channel complex
Current opinion in neurobiology, Vol.13(3), pp.298-307
2003
DOI: 10.1016/S0959-4388(03)00066-7
PMID: 12850214
Abstract
Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits — the pore forming α
1 subunit and the auxiliary α
2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α
1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.
Details
- Title: Subtitle
- Auxiliary subunits: essential components of the voltage-gated calcium channel complex
- Creators
- Jyothi ArikkathKevin P Campbell
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurobiology, Vol.13(3), pp.298-307
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0959-4388(03)00066-7
- PMID
- 12850214
- ISSN
- 0959-4388
- eISSN
- 1873-6882
- Language
- English
- Date published
- 2003
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068386202771
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