Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer

John J Chen; Randy H Kardon

doi:10.1097/WNO.0000000000000422

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Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer

Journal article

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Peer reviewed

Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer

John J Chen and Randy H Kardon

Journal of neuro-ophthalmology, Vol.36(4), pp.417-438

12/2016

DOI: 10.1097/WNO.0000000000000422

PMCID: PMC5113253

PMID: 27636747

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Abstract

Optical coherence tomography (OCT) has become an important tool for diagnosing optic nerve disease. The structural details and reproducibility of OCT continues to improve with further advances in technology. However, artifacts and misinterpretation of OCT can lead to clinical misdiagnosis of diseases if they go unrecognized. A literature review using PubMed combined with clinical and research experience. We describe the most common artifacts and errors in interpretation seen on OCT in both optic nerve and ganglion cell analyses. We provide examples of the artifacts, discuss the causes, and provide methods of detecting them. In addition, we discuss a systematic approach to OCT analysis to facilitate the recognition of artifacts and to avoid clinical misinterpretation. While OCT is invaluable in diagnosing optic nerve disease, we need to be cognizant of the artifacts that can occur with OCT. Failure to recognize some of these artifacts can lead to misdiagnoses and inappropriate investigations.

Nerve Fibers - pathology

Artifacts

Optic Nerve - pathology

Reproducibility of Results

Diagnostic Errors - prevention & control

Humans

Optic Nerve Diseases - diagnosis

Tomography, Optical Coherence - methods

Retinal Ganglion Cells - pathology

Details

Title: Subtitle: Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer
Creators: John J Chen - Mayo Clinic
Randy H Kardon
Resource Type: Journal article
Publication Details: Journal of neuro-ophthalmology, Vol.36(4), pp.417-438
DOI: 10.1097/WNO.0000000000000422
PMID: 27636747
PMCID: PMC5113253
NLM abbreviation: J Neuroophthalmol
ISSN: 1070-8022
eISSN: 1536-5166
Publisher: United States
Language: English
Date published: 12/2016
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980057102771

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