Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum

Stephanie L Alberico; Young-Cho Kim; Tomas Lence; Nandakumar S Narayanan

doi:10.1016/j.neuroscience.2016.11.046

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Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum

Journal article

Peer reviewed

Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum

Stephanie L Alberico, Young-Cho Kim, Tomas Lence and Nandakumar S Narayanan

Neuroscience, Vol.343, pp.240-249

02/20/2017

DOI: 10.1016/j.neuroscience.2016.11.046

PMCID: PMC5262537

PMID: 27956068

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Abstract

Levodopa-induced dyskinesias are abnormal involuntary movements that limit the effectiveness of treatments for Parkinson's disease. Although dyskinesias involve the striatum, it is unclear how striatal neurons are involved in dyskinetic movements. Here we record from striatal neurons in mice during levodopa-induced axial dyskinesias. We developed an automated 3-dimensional motion tracking system to capture the development of axial dyskinesias at ∼10ms resolution, and correlated these movements with neuronal activity of striatal medium spiny neurons and fast-spiking interneurons. The average firing rate of medium spiny neurons increased as axial dyskinesias developed, and both medium spiny neurons and fast-spiking interneurons were modulated around axial dyskinesias. We also found that delta field potential power increased in the striatum with dyskinesia, and that this increased delta power coupled with striatal neurons. Our findings provide insight into how striatal networks change as levodopa-induced dyskinesias develop, and suggest that increased medium spiny neuron firing, increased delta field potential power, and abnormal delta-coupling may be neurophysiological signatures of dyskinesias. These data could be helpful in understanding the role of the striatum in the pathogenesis of dyskinesias in Parkinson's disease.

Corpus Striatum - physiopathology

Dyskinesia, Drug-Induced - physiopathology

Delta Rhythm - drug effects

Mice, Inbred C57BL

Male

Antiparkinson Agents - toxicity

Electrodes, Implanted

Levodopa - toxicity

Functional Laterality

Automation, Laboratory

Animals

Neurons - physiology

Corpus Striatum - drug effects

Pattern Recognition, Automated

Neurons - drug effects

Action Potentials - drug effects

Details

Title: Subtitle: Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum
Creators: Stephanie L Alberico - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
Young-Cho Kim - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
Tomas Lence - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
Nandakumar S Narayanan - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States. Electronic address: Nandakumar-narayanan@uiowa.edu
Resource Type: Journal article
Publication Details: Neuroscience, Vol.343, pp.240-249
DOI: 10.1016/j.neuroscience.2016.11.046
PMID: 27956068
PMCID: PMC5262537
NLM abbreviation: Neuroscience
ISSN: 0306-4522
eISSN: 1873-7544
Publisher: United States
Grant note: T32 GM067795 / NIGMS NIH HHS F31 NS092190 / NINDS NIH HHS R01 NS089470 / NINDS NIH HHS
Language: English
Date published: 02/20/2017
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984013922902771

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