Journal article
Axon-Schwann cell interactions regulate the expression of c-jun in Schwann cells
Journal of neuroscience research, Vol.43(5), pp.511-525
03/01/1996
DOI: 10.1002/(SICI)1097-4547(19960301)43:5<511::AID-JNR1>3.0.CO;2-L
PMID: 8833086
Abstract
The transcription factor c-jun is selectively expressed by non-myelinating Schwann cells in normal peripheral nerve, and be "denervated," previously myelinatng Schwann cells, after axotomy. When axons regenerate into the distal nerve-stump, the expression of c-jun declines as Schwann cells remyelinate axons. Treating cultured Schwann cells with forskolin, a drug that mimics many of the effects of axon-Schwann cell interactions, decreases the expression of myelin-specific genes. Overexpressing c-jun in cultured Schwann cells, however, does not decrease the expression of a myelin basic protein promoter-reporter construct, indicating that c-jun expression may not directly regulate myelin-specific gene expression. These data suggest that c-jun is invloved in regulating the phenotype of non-myelinating and denervated Schwann cells.
Details
- Title: Subtitle
- Axon-Schwann cell interactions regulate the expression of c-jun in Schwann cells
- Creators
- M E Shy - Department of Neurology, Wayne State University, Detroit, Michigan, USAY ShiL WrabetzJ KamholzS S Scherer
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience research, Vol.43(5), pp.511-525
- Publisher
- United States
- DOI
- 10.1002/(SICI)1097-4547(19960301)43:5<511::AID-JNR1>3.0.CO;2-L
- PMID
- 8833086
- ISSN
- 0360-4012
- eISSN
- 1097-4547
- Grant note
- NS-08075 / NINDS NIH HHS 466 / Telethon NS-01261 / NINDS NIH HHS NS-01565 / NINDS NIH HHS
- Language
- English
- Date published
- 03/01/1996
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020650102771
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