Journal article
Axonal channelopathies : An evolving concept in the pathogenesis of peripheral nerve disorders
Neurology, Vol.47(1), pp.18-21
1996
DOI: 10.1212/WNL.47.1.18
PMID: 8710074
Abstract
Abnormalities of peripheral nerve Na+ and K+ channels result in clinical manifestations unrelated to axonal degeneration or demyelination. Na+ channel blockade causes weakness and sensory loss associated with slowed conduction and decreased motor and sensory action potential amplitudes. K+ channel abnormalities result in high frequency repetitive action potentials (e.g., myokymia). Ion channel abnormalities may also play an important role in electrophysiologic changes seen in demyelinating disorders.
Details
- Title: Subtitle
- Axonal channelopathies : An evolving concept in the pathogenesis of peripheral nerve disorders
- Creators
- Ludwig Gutmann - Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, United StatesLaurie Gutmann - Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, United States
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.47(1), pp.18-21
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- DOI
- 10.1212/WNL.47.1.18
- PMID
- 8710074
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 1996
- Academic Unit
- Neurology
- Record Identifier
- 9984013277502771
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