Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene

Shawn R Lockhart; João P Frade; Kizee A Etienne; Michael A Pfaller; Daniel J Diekema; S Arunmozhi Balajee

doi:10.1128/AAC.00185-11

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Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene

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Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene

Shawn R Lockhart, João P Frade, Kizee A Etienne, Michael A Pfaller, Daniel J Diekema and S Arunmozhi Balajee

Antimicrobial agents and chemotherapy, Vol.55(9), pp.4465-4468

09/2011

DOI: 10.1128/AAC.00185-11

PMCID: PMC3165364

PMID: 21690285

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Abstract

We surveyed 497 isolates of Aspergillus fumigatus collected from 2008 to 2009 as part of the ARTEMIS global surveillance study for elevated MIC values to itraconazole, voriconazole, and posaconazole. Sequencing of the cyp51A gene revealed that 8/29 isolates with elevated MIC values to one or more triazoles, all originating in China, contained the TR/L98H mutation associated with resistant European isolates of A. fumigatus. This is the first time the TR/L98H mutation has been identified outside Europe.

Antifungal Agents - pharmacology

Aspergillus fumigatus - drug effects

Microbial Sensitivity Tests

Cytochrome P-450 Enzyme System - genetics

Drug Resistance, Fungal - genetics

Fungal Proteins - genetics

Mutation

Aspergillus fumigatus - genetics

Itraconazole - pharmacology

Details

Title: Subtitle: Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene
Creators: Shawn R Lockhart - Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA. gyi2@cdc.gov
João P Frade
Kizee A Etienne
Michael A Pfaller
Daniel J Diekema
S Arunmozhi Balajee
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.55(9), pp.4465-4468
DOI: 10.1128/AAC.00185-11
PMID: 21690285
PMCID: PMC3165364
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 1098-6596
eISSN: 1098-6596
Publisher: United States
Language: English
Date published: 09/2011
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986374902771

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