B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study

Cheng Chen; Eric A Whitsel; Mark A Espeland; Linda Snetselaar; Kathleen M Hayden; Archana P Lamichhane; Marc L Serre; William Vizuete; Joel D Kaufman; Xinhui Wang; Helena C Chui; Mary E D'Alton; Jiu-Chiuan Chen; Ka Kahe

doi:10.1002/alz.12515

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B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study

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B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study

Cheng Chen, Eric A Whitsel, Mark A Espeland, Linda Snetselaar, Kathleen M Hayden, Archana P Lamichhane, Marc L Serre, William Vizuete, Joel D Kaufman, Xinhui Wang, …

Alzheimer's & dementia, Vol.18(11), pp.2188-2198

11/2022

DOI: 10.1002/alz.12515

PMCID: PMC9339592

PMID: 35103387

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Abstract

Introduction Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B12, and B6) modified the association between PM2.5 exposure and incidence of all-cause dementia. Methods This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3-year average PM2.5 exposure was estimated using a spatiotemporal model. Results During a mean follow-up of 9 years, 342 participants developed all-cause dementia. We found that residing in locations with PM2.5 exposure above the regulatory standard (12 μg/m3) was associated with a higher risk of dementia only among participants with lower intakes of these B vitamins. Discussion This is the first study suggesting that the putative neurotoxicity of PM2.5 exposure may be attenuated by high B vitamin intakes.

Dementia

vitamin B6

folate

vitamin B12

fine particulate matter

PM2.5

Details

Title: Subtitle: B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study
Creators: Cheng Chen - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Eric A Whitsel - Department of Epidemiology, Gillings School of Global Public Health, Department of Medicine, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
Mark A Espeland - Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Linda Snetselaar - Department of Epidemiology, College of Public Health, the University of Iowa, Iowa City, Iowa, USA
Kathleen M Hayden - Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
Archana P Lamichhane - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Marc L Serre - Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
William Vizuete - Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Joel D Kaufman - Department of Environmental and Occupational Health Sciences, Department of Medicine, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
Xinhui Wang - Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Helena C Chui - Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Mary E D'Alton - Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA
Jiu-Chiuan Chen - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Ka Kahe - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Resource Type: Journal article
Publication Details: Alzheimer's & dementia, Vol.18(11), pp.2188-2198
DOI: 10.1002/alz.12515
PMID: 35103387
PMCID: PMC9339592
NLM abbreviation: Alzheimers Dement
eISSN: 1552-5279
Grant note: HHSN268201600018C / NHLBI NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS NHLBI NIH HHS NIH HHS
Language: English
Electronic publication date: 02/01/2022
Date published: 11/2022
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215048602771

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