BBSome: An essential component of hypothalamic regulation of energy homeostasis

Deng Fu Guo; Yuying Zhao; Connor Laule; Kamal Rahmouni

doi:10.1007/s11154-025-09979-0

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BBSome: An essential component of hypothalamic regulation of energy homeostasis

Journal article

Open access

Peer reviewed

BBSome: An essential component of hypothalamic regulation of energy homeostasis

Deng Fu Guo, Yuying Zhao, Connor Laule and Kamal Rahmouni

Reviews in endocrine & metabolic disorders, Vol.27(3), pp.479-491

06/2026

DOI: 10.1007/s11154-025-09979-0

PMCID: PMC13246823

PMID: 40560450

Appears in UI Libraries Support Open Access

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Abstract

The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins. Although the BBSome is best known for its role in regulating cilia function, accumulating evidence indicates that this protein complex is also involved in various cellular processes, including mitochondrial dynamics and receptor trafficking to the plasma membrane. BBSome deficiency is associated with a range of diseases, including obesity and type 2 diabetes. Research into the mechanisms underlying metabolic disorders caused by BBSome deficiency has uncovered novel pathways of metabolic regulation, particularly within the hypothalamus. In this review, we discuss recent advances in understanding the role of the hypothalamic BBSome in the control of energy and glucose homeostasis and explore the underlying mechanisms.

Metabolism

Obesity

Clia

Bardet-Biedl syndrome

Hypothalamus

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Details

Title: Subtitle: BBSome: An essential component of hypothalamic regulation of energy homeostasis
Creators: Deng Fu Guo - Veterans Affairs Health Care System, Iowa City, Iowa, USA
Yuying Zhao - University of Iowa
Connor Laule - University of Iowa
Kamal Rahmouni - Iowa City VA Health Care System
Resource Type: Journal article
Publication Details: Reviews in endocrine & metabolic disorders, Vol.27(3), pp.479-491
DOI: 10.1007/s11154-025-09979-0
PMID: 40560450
PMCID: PMC13246823
NLM abbreviation: Rev Endocr Metab Disord
ISSN: 1573-2606
eISSN: 1573-2606
Publisher: Springer Nature
Grant note: BX004249, BX006040 / U.S. Department of Veterans Affairs HL168820, R01 HL162773, R01 HL172944 / NIH HHS
Language: English
Electronic publication date: 06/25/2025
Date published: 06/2026
Academic Unit: Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984833510402771

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