Journal article
BBSome: An essential component of hypothalamic regulation of energy homeostasis
Reviews in endocrine & metabolic disorders
06/25/2025
DOI: 10.1007/s11154-025-09979-0
PMID: 40560450
Appears in UI Libraries Support Open Access
Abstract
The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins. Although the BBSome is best known for its role in regulating cilia function, accumulating evidence indicates that this protein complex is also involved in various cellular processes, including mitochondrial dynamics and receptor trafficking to the plasma membrane. BBSome deficiency is associated with a range of diseases, including obesity and type 2 diabetes. Research into the mechanisms underlying metabolic disorders caused by BBSome deficiency has uncovered novel pathways of metabolic regulation, particularly within the hypothalamus. In this review, we discuss recent advances in understanding the role of the hypothalamic BBSome in the control of energy and glucose homeostasis and explore the underlying mechanisms.
Details
- Title: Subtitle
- BBSome: An essential component of hypothalamic regulation of energy homeostasis
- Creators
- Deng Fu Guo - Veterans Affairs Health Care System, Iowa City, Iowa, USAYuying Zhao - University of IowaConnor Laule - University of IowaKamal Rahmouni - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- Reviews in endocrine & metabolic disorders
- DOI
- 10.1007/s11154-025-09979-0
- PMID
- 40560450
- NLM abbreviation
- Rev Endocr Metab Disord
- ISSN
- 1573-2606
- eISSN
- 1573-2606
- Publisher
- Springer Nature
- Grant note
- BX004249, BX006040 / U.S. Department of Veterans Affairs HL168820, R01 HL162773, R01 HL172944 / NIH HHS
- Language
- English
- Electronic publication date
- 06/25/2025
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984833510402771
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