BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation

Gowri Satyanarayana; Sarah P. Hammond; Thomas A. Broge; Matthew R. Mackenzie; Raphael Viscidi; Ioannis Politikos; Igor J. Koralnik; Corey S. Cutler; Karen Ballen; Vassiliki Boussiotis; Francisco M. Marty; Chen Sabrina Tan

doi:10.1016/j.trim.2014.12.002

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BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation

Journal article

Open access

Peer reviewed

BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation

Gowri Satyanarayana, Sarah P. Hammond, Thomas A. Broge, Matthew R. Mackenzie, Raphael Viscidi, Ioannis Politikos, Igor J. Koralnik, Corey S. Cutler, Karen Ballen, Vassiliki Boussiotis, …

Transplant immunology, Vol.32(2), pp.116-120

03/2015

DOI: 10.1016/j.trim.2014.12.002

PMCID: PMC4368450

PMID: 25536223

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https://www.ncbi.nlm.nih.gov/pmc/articles/4368450View

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Abstract

Serial serum samples from 27 patients who underwent double umbilical cord blood transplantation (dUCBT) were analyzed for BK polyomavirus (BKPyV) DNA by real-time PCR and BKPyV-specific immune globulin by ELISA. Clinical data were collected on all patients. All pre-transplant sera had detectable anti-BKPyV IgG. Fifteen patients (56%) had detectable serum BKPyV DNA (median 8.9×104copies/ml; range 4.1×103–7.9×106copies/ml) a median of 40days (range, 27–733days) after dUCBT, with highest viral loads on Day 100 assessment. The cumulative probability of developing BKPyV viremia by Day 100 was 0.52 (95% CI, 0.33–0.71). Six of 15 patients with BKPyV viremia experienced hemorrhagic cystitis by Day 100. By Day 100, there was a trend towards higher BKPyV viral loads in sera of patients with hemorrhagic cystitis than in those BKPyV viremic patients without hemorrhagic cystitis (p=0.06). BKPyV viremia was associated with significantly higher anti-BKPyV IgM values at 6months post-dUCBT (P=0.003). BKPyV viremia occurs early after dUBCT and is associated with a detectable humoral immune response by 6months post-dUBCT. •BK polyomavirus reactivation occurred in 56% of patients in this cohort.•BK polyomavirus reactivation peaked by Day 100 after HCT.•At 6months after HCT, anti-BKPyV IgM was higher in those patients who had BKPyV viremia.

BK polyomavirus

Hemorrhagic cystitis

Viral reactivation

Details

Title: Subtitle: BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation
Creators: Gowri Satyanarayana - Brigham and Women's Hospital
Sarah P. Hammond - Brigham and Women's Hospital
Thomas A. Broge - Beth Israel Deaconess Medical Center
Matthew R. Mackenzie - Beth Israel Deaconess Medical Center
Raphael Viscidi - Johns Hopkins University
Ioannis Politikos - Beth Israel Deaconess Medical Center
Igor J. Koralnik - Beth Israel Deaconess Medical Center
Corey S. Cutler - Dana-Farber Cancer Institute
Karen Ballen - Massachusetts General Hospital
Vassiliki Boussiotis - Beth Israel Deaconess Medical Center
Francisco M. Marty - Brigham and Women's Hospital
Chen Sabrina Tan - Harvard University
Resource Type: Journal article
Publication Details: Transplant immunology, Vol.32(2), pp.116-120
DOI: 10.1016/j.trim.2014.12.002
PMID: 25536223
PMCID: PMC4368450
NLM abbreviation: Transpl Immunol
ISSN: 0966-3274
eISSN: 1878-5492
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: NIH, award: R01 NS 047029, NS 074995, NS R56 041198, K24 NS 060950; DOI: 10.13039/100000002, name: NIH, award: K08 NS 064215-01
Language: English
Date published: 03/2015
Academic Unit: Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9984366278802771

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