Journal article
BK virus histopathologic disease severity does not predict allograft outcome in renal transplant recipients
Annals of diagnostic pathology, Vol.42, pp.1-6
10/2019
DOI: 10.1016/j.anndiagpath.2019.06.012
PMID: 31302370
Abstract
BK polyomavirus nephropathy (BKPyVN) is an important cause of allograft failure after renal transplantation. Despite early screening for the virus, allograft loss from BKPyVN is still experienced in up to 14% of all renal transplant recipients. The aim of this study was to investigate the association between BKPyVN histopathologic disease severity and allograft outcome at our center.
Kidney transplant recipients who had undergone transplantation between 2002 and 2014 with biopsy proven BKPyVN were eligible for this retrospective study. Each biopsy was re-evaluated by a single pathologist blinded to the clinical data and scored according to the Banff criteria for rejection and BKPyVN. Serum creatinine and BK viral load at the time of biopsy diagnosis as well as allograft outcomes to include allograft survival and serum BK viremia resolution were collected for each recipient to determine if BK virus histopathologic disease severity could predict allograft outcome.
Twenty cases of BKPyVN were identified from 1031 total renal transplants performed. There was no statistical association between allograft loss and BKPyVN histopathology (p = 0.49). There was also no statistical association between BKPyVN histopathology and BK viral load at the time of biopsy diagnosis (p = 0.38) or serum BK viremia resolution (p = 0.16).
BKPyVN histopathology does not appear to be useful in predicting renal allograft outcome in those recipients diagnosed with BKPyVN which is in contrast to some previously published data.
•BK polyomavirus nephropathy contributes to allograft loss after kidney transplantation.•Kidney allograft biopsies can be classified into grades reflecting BK disease severity.•Limited clinicopathological correlation between disease severity and allograft outcome
Details
- Title: Subtitle
- BK virus histopathologic disease severity does not predict allograft outcome in renal transplant recipients
- Creators
- M. Lee Sanders - University of IowaMelissa Swee - University of IowaMony Fraer - University of IowaSarat Kuppachi - University of IowaPatrick Ten Eyck - University of IowaPrerna Rastogi - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of diagnostic pathology, Vol.42, pp.1-6
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.anndiagpath.2019.06.012
- PMID
- 31302370
- ISSN
- 1092-9134
- eISSN
- 1532-8198
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Stead Family Department of Pediatrics; Pathology; Biostatistics; Nephrology; Internal Medicine
- Record Identifier
- 9984186636302771
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