Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling

Josep C Jiménez-Chillarón; Mark J Nijland; António A Ascensão; Vilma A Sardão; José Magalhães; Michael J Hitchler; Frederick E Domann; Paulo J Oliveira

doi:10.1080/15592294.2015.1020267

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Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling

Josep C Jiménez-Chillarón, Mark J Nijland, António A Ascensão, Vilma A Sardão, José Magalhães, Michael J Hitchler, Frederick E Domann and Paulo J Oliveira

Epigenetics, Vol.10(4), pp.259-273

04/03/2015

DOI: 10.1080/15592294.2015.1020267

PMCID: PMC4622959

PMID: 25774863

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Abstract

Epigenetics, or regulation of gene expression independent of DNA sequence, is the missing link between genotype and phenotype. Epigenetic memory, mediated by histone and DNA modifications, is controlled by a set of specialized enzymes, metabolite availability, and signaling pathways. A mostly unstudied subject is how sub-toxic exposure to several xenobiotics during specific developmental stages can alter the epigenome and contribute to the development of disease phenotypes later in life. Furthermore, it has been shown that exposure to low-dose xenobiotics can also result in further epigenetic remodeling in the germ line and contribute to increase disease risk in the next generation (multigenerational and transgenerational effects). We here offer a perspective on current but still incomplete knowledge of xenobiotic-induced epigenetic alterations, and their possible transgenerational transmission. We also propose several molecular mechanisms by which the epigenetic landscape may be altered by environmental xenobiotics and hypothesize how diet and physical activity may counteract epigenetic alterations.

toxicology

metabolism

transgenerational effects

circadian clock

epigenetics

Details

Title: Subtitle: Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling
Creators: Josep C Jiménez-Chillarón - Endocrine Division; Hospital Sant Joan de Déu
Mark J Nijland - University of Texas Health Science Center
António A Ascensão - Department of Sports Biology, University of Porto
Vilma A Sardão - CNC - Center for Neuroscience and Cell Biology; University of Coimbra
José Magalhães - Department of Sports Biology, University of Porto
Michael J Hitchler - Department of Radiation Oncology; Kaiser Permanente
Frederick E Domann - Carver College of Medicine, and Holden Comprehensive Cancer Center; The University of Iowa
Paulo J Oliveira - CNC - Center for Neuroscience and Cell Biology; University of Coimbra
Resource Type: Journal article
Publication Details: Epigenetics, Vol.10(4), pp.259-273
Publisher: Taylor & Francis
DOI: 10.1080/15592294.2015.1020267
PMID: 25774863
PMCID: PMC4622959
ISSN: 1559-2294
eISSN: 1559-2308
Language: English
Date published: 04/03/2015
Academic Unit: Pathology; Surgery; Radiation Oncology
Record Identifier: 9984047668802771

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