Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics

Agnieszka K. Muszanska; M. Reza Nejadnik; Yun Chen; Edwin R. van den Heuvel; Henk J. Busscher; Henny C. van der Mei; Willem Norde

doi:10.1128/AAC.00431-12

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Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics

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Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics

Agnieszka K. Muszanska, M. Reza Nejadnik, Yun Chen, Edwin R. van den Heuvel, Henk J. Busscher, Henny C. van der Mei and Willem Norde

Antimicrobial agents and chemotherapy, Vol.56(9), pp.4961-4964

09/01/2012

DOI: 10.1128/AAC.00431-12

PMCID: PMC3421903

PMID: 22733073

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Abstract

Biofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains of Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa adhered more weakly to brush-coated silicone rubber (-0.05 +/- 0.03 to -0.51 +/- 0.62 nN) than to uncoated silicone rubber (-1.05 +/- 0.46 to -5.1 +/- 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.

Life Sciences & Biomedicine

Microbiology

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics
Creators: Agnieszka K. Muszanska - University Medical Center Groningen
M. Reza Nejadnik - University Medical Center Groningen
Yun Chen - University Medical Center Groningen
Edwin R. van den Heuvel - University Medical Center Groningen
Henk J. Busscher - University Medical Center Groningen
Henny C. van der Mei - University Medical Center Groningen
Willem Norde - University Medical Center Groningen
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.56(9), pp.4961-4964
DOI: 10.1128/AAC.00431-12
PMID: 22733073
PMCID: PMC3421903
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Publisher: Amer Soc Microbiology
Number of pages: 4
Grant note: University Medical Center, Groningen, The Netherlands; Netherlands Government
Language: English
Date published: 09/01/2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984420835602771

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