Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system

P S Schlievert; W Johnson; R P Galask

doi:10.1016/0002-9378(76)90486-5

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Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system

Journal article

Peer reviewed

Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system

P S Schlievert, W Johnson and R P Galask

American journal of obstetrics and gynecology, Vol.125(7), pp.906-910

08/01/1976

DOI: 10.1016/0002-9378(76)90486-5

PMID: 782249

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Abstract

The zinc bacterial inhibitory activity of amniotic fluid is dependent on the presence of a second, organic component contained in amniotic fluid. The second component is heat stable, resists proteolytic digestion, and is present in amniotic fluid throughout pregnancy. Further, the component may be a peptide with a molecular weight of less than 5,000 daltons. Phosphate reversal of amniotic fluid inhibitory activity may result from interference with the organic component rather than zinc.

Pregnancy

Escherichia coli - drug effects

Humans

Amniotic Fluid - analysis

Biological Assay

Female

Zinc - pharmacology

Phosphates - pharmacology

Peptides - analysis

Peptides - pharmacology

Details

Title: Subtitle: Bacterial growth inhibition by amniotic fluid. VI. Evidence for a zinc-peptide antibacterial system
Creators: P S Schlievert
W Johnson
R P Galask
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.125(7), pp.906-910
DOI: 10.1016/0002-9378(76)90486-5
PMID: 782249
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: United States
Language: English
Date published: 08/01/1976
Academic Unit: Dermatology; Neurology; Molecular Physiology and Biophysics; Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001228902771

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