Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations

P Schlievert; B Larsen; W Johnson; R P Galask

doi:10.1016/0002-9378(75)90720-6

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Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations

Journal article

Peer reviewed

Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations

P Schlievert, B Larsen, W Johnson and R P Galask

American journal of obstetrics and gynecology, Vol.122(7), pp.814-819

08/01/1975

DOI: 10.1016/0002-9378(75)90720-6

PMID: 1096617

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Abstract

Bacterial growth inhibition in amniotic fluid is associated with a compound or class of compounds which resembles antibacterial cationic peptides. The inhibitor studied in amniotic fluid is sensitive to treatment with monobasic and dibasic potassium phosphate, and the inhibitory activity of amniotic fluid is lost following adsorption onto bentomite. The inhibitory component in amniotic fluid interacts with bacterial cells by adsorption or is internalized by viable cells only. The inhibitory quality of amniotic fluid is not destroyed by heating to 100 degrees C. for 15 minutes, and this heat-stable inhibitory activity is associated with the compound or compounds which are phosphate sensitive. A possible mode of antibacterial action which is consistent with the data presented is discussed.

Amniocentesis

Escherichia coli - drug effects

Humans

Hot Temperature

Pregnancy

Bentonite - pharmacology

Amniotic Fluid

Adsorption

Culture Media

Bacteriological Techniques

Female

Escherichia coli - growth & development

Phosphates - pharmacology

Details

Title: Subtitle: Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations
Creators: P Schlievert
B Larsen
W Johnson
R P Galask
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.122(7), pp.814-819
DOI: 10.1016/0002-9378(75)90720-6
PMID: 1096617
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: United States
Language: English
Date published: 08/01/1975
Academic Unit: Dermatology; Neurology; Molecular Physiology and Biophysics; Microbiology and Immunology; Internal Medicine
Record Identifier: 9984002391702771

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