Journal article
Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production
The Journal of experimental medicine, Vol.181(2), pp.747-753
02/01/1995
DOI: 10.1084/jem.181.2.747
PMCID: PMC2191866
PMID: 7836926
Abstract
T lymphocyte infiltration is a prominent feature of the skin inflammation associated with infections by toxin (superantigen)-secreting Staphylococcus aureus or Streptococcus bacteria. The cutaneous lymphocyte-associated antigen (CLA) has been hypothesized to be a homing receptor (HR) involved in selective migration of memory/effector T cells to the skin. Since the expression of this putative skin-selective HR is known to be under strict microenvironmental control, we sought to determine the effect of staphylococcal and streptococcal toxins on T cell expression of CLA. After in vitro stimulation of peripheral blood mononuclear cells with staphylococcal enterotoxin B, toxic shock syndrome toxin-1, and streptococcal pyrogenic exotoxins A and C, there was a significant increase in the numbers of CLA+ T cell blasts (p < 0.01), but not blasts bearing the mucosa-associated adhesion molecule alpha e beta 7-integrin, compared with T cells stimulated with phytohemaglutinin (PHA) or anti-CD3. Bacterial toxins were also found to specifically induce interleukin (IL) 12 production. More importantly, induction of toxin-induced CLA expression was blocked by anti-IL-12, and the addition of IL-12 to PHA-stimulated T cells induced CLA, but not alpha e beta 7-integrin, expression. These data suggest that bacterial toxins induce the expansion of skin-homing CLA+ T cells in an IL-12-dependent manner, and thus may contribute to the development of skin rashes in superantigen-mediated diseases.
Details
- Title: Subtitle
- Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production
- Creators
- Donald Y M Leung - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206Maurice GatelyAnne Trumble - Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206Bonnie Ferguson-Darnell - The University of Texas Southwestern Medical CenterPatrick M Schlievert - University of Minnesota Medical SchoolLouis J Picker - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.181(2), pp.747-753
- DOI
- 10.1084/jem.181.2.747
- PMID
- 7836926
- PMCID
- PMC2191866
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 02/01/1995
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001225402771
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