Journal article
Balance impairment in pediatric charcot-marie-tooth disease
Muscle & nerve, Vol.60(3), pp.242-249
09/2019
DOI: 10.1002/mus.26500
PMID: 31026080
Abstract
Balance impairment contributes to gait dysfunction, falls, and reduced quality of life in adults with Charcot-Marie-Tooth disease (CMT) but has been minimally examined in pediatric CMT.
The CMT Pediatric Scale (CMTPedS) was administered to 520 children with CMT. Associations between balance function (Bruininks-Oseretsky Test of Motor Proficiency [BOT-2]) and sensorimotor and gait impairments were investigated.
Daily trips/falls were reported by 42.3% of participants. Balance (BOT-2) varied by CMT subtype, was impaired in 42% of 4-year-olds, and declined with age (P < 0.001). Vibration (P < 0.001), pinprick (P < 0.004), ankle dorsiflexion strength (P < 0.001), and foot alignment (P < 0.004) were associated with BOT-2 balance (adjusted R
= 0.28). The visual dependence of balance increased with age.
Balance impairment occurs from a young age in children with CMT. Balance intervention studies are required in pediatric CMT and should consider the degree of sensorimotor impairment, foot malalignment, and visual dependence. Muscle Nerve, 2019.
Details
- Title: Subtitle
- Balance impairment in pediatric charcot-marie-tooth disease
- Creators
- Timothy Estilow - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USAAllan M Glanzman - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USAJoshua Burns - The University of Sydney & Children's Hospital at Westmead, Sydney, AustraliaAnn Harrington - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USAKayla Cornett - The University of Sydney & Children's Hospital at Westmead, Sydney, AustraliaManoj P Menezes - The University of Sydney & Children's Hospital at Westmead, Sydney, AustraliaRosemary Shy - Carver College of Medicine, Department of Pediatrics, University of Iowa, Iowa City, Iowa, USAIsabella Moroni - IRCCS Foundation, Carlo Besta Neurological Institute, Milan, ItalyEmanuela Pagliano - IRCCS Foundation, Carlo Besta Neurological Institute, Milan, ItalyDavide Pareyson - IRCCS Foundation, Carlo Besta Neurological Institute, Milan, ItalyTrupti Bhandari - UCL Institute of Child Health & Great Ormond Street Hospital, London, United KingdomFrancesco Muntoni - UCL Institute of Child Health & Great Ormond Street Hospital, London, United KingdomMatilde Laurá - MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London, United KingdomMary M Reilly - MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, Queen Square, London, United KingdomRichard S Finkel - Neuromuscular Program, Division of Neurology, Nemours Children's Hospital, Orlando, Florida, USAKate J Eichinger - Department of Neurology, University of Rochester, Rochester, New York, USADavid N Herrmann - Department of Neurology, University of Rochester, Rochester, New York, USAGregory Troutman - Department of Biostatistics and Clinical Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USAPaula Bray - The University of Sydney & Children's Hospital at Westmead, Sydney, AustraliaMark Halaki - Carver College of Medicine, Department of Neurology, University of Iowa, Iowa City, Iowa, USAMichael E Shy - Carver College of Medicine, Department of Neurology, University of Iowa, Iowa City, Iowa, USASabrina W Yum - Children's Hospital of Philadelphia, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Resource Type
- Journal article
- Publication Details
- Muscle & nerve, Vol.60(3), pp.242-249
- DOI
- 10.1002/mus.26500
- PMID
- 31026080
- NLM abbreviation
- Muscle Nerve
- ISSN
- 0148-639X
- eISSN
- 1097-4598
- Publisher
- United States
- Grant note
- G0601943 / Medical Research Council MR/K000608/1 / Medical Research Council U54 NS065712 / NINDS NIH HHS
- Language
- English
- Date published
- 09/2019
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984070109002771
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