Journal article
Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria
Virulence, Vol.11(1), pp.159-169
01/01/2020
DOI: 10.1080/21505594.2020.1726569
PMCID: PMC7051139
PMID: 32043415
Abstract
Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to severe anemia and fatality. However, the same inflammatory response that controls parasite replication is also associated with immunopathology and severe disease, as is exemplified by cerebral malaria. A robust literature has identified critical roles for innate, cellular, and humoral immune responses orchestrated by IFN-γ and T
H
1 type responses in controlling blood stage malarial disease. In contrast, TGF-β and IL-10 have been identified as important anti-inflammatory immunomodulators that help to limit inflammation and pathology during malaria. TGF-β is a pleiotropic cytokine, with the ability to exert a wide variety of context-dependent immunomodulatory roles.
The specific mechanisms that allow TGF-β to protect against malarial pathology remain essentially unexplored and offer a promising avenue to dissect the most critical elements of immunomodulation in avoiding severe malaria. Here we discuss potential immunomodulatory roles for TGF-β during malaria in light of recent advances in our understanding of the role of Tregs during blood-stage malaria.
Details
- Title: Subtitle
- Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria
- Creators
- Lisa L Drewry - University of IowaJohn T Harty - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Virulence, Vol.11(1), pp.159-169
- DOI
- 10.1080/21505594.2020.1726569
- PMID
- 32043415
- PMCID
- PMC7051139
- NLM abbreviation
- Virulence
- ISSN
- 2150-5594
- eISSN
- 2150-5608
- Publisher
- Taylor & Francis
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: AI42767; DOI: 10.13039/100000002, name: National Institutes of Health, award: AI85515; DOI: 10.13039/100000002, name: National Institutes of Health, award: AI007260; DOI: 10.13039/100000002, name: National Institutes of Health, award: AI114543; DOI: 10.13039/100000002, name: National Institutes of Health, award: AI100527
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984186541002771
Metrics
32 Record Views