Banff 2013 Meeting Report: Inclusion of C4d‐Negative Antibody‐Mediated Rejection and Antibody‐Associated Arterial Lesions

M Haas; B Sis; L. C Racusen; K Solez; D Glotz; R. B Colvin; M. C. R Castro; D. S. R David; E David‐Neto; S. M Bagnasco; L. C Cendales; L. D Cornell; A. J Demetris; C. B Drachenberg; C. F Farver; A. B Farris; I. W Gibson; E Kraus; H Liapis; A Loupy; V Nickeleit; P Randhawa; E. R Rodriguez; D Rush; R. N Smith; C. D Tan; W. D Wallace; M Mengel; Banff meeting report writing committee

doi:10.1111/ajt.12590

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Banff 2013 Meeting Report: Inclusion of C4d‐Negative Antibody‐Mediated Rejection and Antibody‐Associated Arterial Lesions

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Banff 2013 Meeting Report: Inclusion of C4d‐Negative Antibody‐Mediated Rejection and Antibody‐Associated Arterial Lesions

M Haas, B Sis, L. C Racusen, K Solez, D Glotz, R. B Colvin, M. C. R Castro, D. S. R David, E David‐Neto, S. M Bagnasco, …

American journal of transplantation, Vol.14(2), pp.272-283

02/2014

DOI: 10.1111/ajt.12590

PMID: 24472190

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Abstract

The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19–23, 2013, and was preceded by a 2‐day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working groups formed at the 2009 and 2011 Banff meetings to: (1) establish consensus criteria for diagnosing antibody‐mediated rejection (ABMR) in the presence and absence of detectable C4d deposition; (2) develop consensus definitions and thresholds for glomerulitis (g score) and chronic glomerulopathy (cg score), associated with improved inter‐observer agreement and correlation with clinical, molecular and serological data; (3) determine whether isolated lesions of intimal arteritis (“isolated v”) represent acute rejection similar to intimal arteritis in the presence of tubulointerstitial inflammation; (4) compare different methodologies for evaluating interstitial fibrosis and for performing/evaluating implantation biopsies of renal allografts with regard to reproducibility and prediction of subsequent graft function; and (5) define clinically and prognostically significant morphologic criteria for subclassifying polyoma virus nephropathy. The key outcome of the 2013 conference is defining criteria for diagnosis of C4d‐negative ABMR and respective modification of the Banff classification. In addition, three new Banff Working Groups were initiated. The 2013 Banff Transplant Conference defines revised, consensus criteria for acute/active and chronic, active antibody‐mediated rejection in renal allograft biopsies, criteria that include C4d‐negative antibody‐mediated rejection and antibody‐associated arterial lesions. Also see comprehensive review by Djamali et al on page 255.

cardiac allograft

Acute allograft rejection

composite tissue allograft

donor‐specific antibodies

transplant biopsy

renal transplantation

complement C4d

transplant glomerulopathy

Banff schema

chronic allograft rejection

transplant pathology

lung transplantation

antibody‐mediated rejection

liver allograft

pancreas allograft

Details

Title: Subtitle: Banff 2013 Meeting Report: Inclusion of C4d‐Negative Antibody‐Mediated Rejection and Antibody‐Associated Arterial Lesions
Creators: M Haas - Cedars‐Sinai Medical Center
B Sis - University of Alberta
L. C Racusen - Johns Hopkins University School of Medicine
K Solez - University of Alberta
D Glotz - Hopital Saint‐Louis
R. B Colvin - Harvard Medical School and Massachusetts General Hospital
M. C. R Castro - University of Sao Paolo
D. S. R David - University of Sao Paolo
E David‐Neto - University of Sao Paolo
S. M Bagnasco - Johns Hopkins University School of Medicine
L. C Cendales - Emory University School of Medicine and Atlanta Veterans Affairs Medical Center
L. D Cornell - Mayo Clinic
A. J Demetris - University of Pittsburgh
C. B Drachenberg - University of Maryland School of Medicine
C. F Farver - Cleveland Clinic
A. B Farris - Emory University School of Medicine
I. W Gibson - University of Manitoba Health Sciences Centre
E Kraus - Johns Hopkins University School of Medicine
H Liapis - Washington University School of Medicine
A Loupy - Necker Hospital
V Nickeleit - University of North Carolina at Chapel Hill
P Randhawa - University of Pittsburgh
E. R Rodriguez - Cleveland Clinic
D Rush - University of Manitoba Health Sciences Centre
R. N Smith - Harvard Medical School and Massachusetts General Hospital
C. D Tan - Cleveland Clinic
W. D Wallace - University of California
M Mengel - University of Alberta
Banff meeting report writing committee
Contributors: Danniele Holanda (Contributor) - University of Iowa, Pathology
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.14(2), pp.272-283
DOI: 10.1111/ajt.12590
PMID: 24472190
ISSN: 1600-6135
eISSN: 1600-6143
Number of pages: 12
Grant note: Roche Organ Transplant Research Foundation Thermo Fisher (former One Lambda) University of Alberta Transpath, Inc. The Transplantation Society Canadian Society of Transplantation Sociedad de Transplante de Latinoamerica y Caribe Alexion Libbs Associacao Brasileira de Transplante de Orgaos Kajoma CNPQ‐Brasil Sanofi American Society of Transplantation Baxter Associacao Brasileira de Histocompatibilidade Banff Foundation for Allograft Pathology Astellas
Language: English
Date published: 02/2014
Academic Unit: Pathology
Record Identifier: 9984046908002771

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