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Barrett's esophagus: progression to adenocarcinoma and markers
Journal article   Peer reviewed

Barrett's esophagus: progression to adenocarcinoma and markers

Dianchun Fang, Kiron M Das, Weibiao Cao, Usha Malhotra, George Triadafilopoulos, Robert M Najarian, Laura J Hardie, Charles J Lightdale, Ian L P Beales, Valter Nilton Felix, …
Annals of the New York Academy of Sciences, Vol.1232(1), pp.210-229
09/2011
DOI: 10.1111/j.1749-6632.2011.06053.x
PMID: 21950815

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Abstract

The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.
Adenocarcinoma - pathology Barrett Esophagus - pathology Humans NADPH Oxidases - metabolism Reverse Transcriptase Polymerase Chain Reaction Biomarkers, Tumor Disease Progression Esophageal Neoplasms - pathology

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