Basal forebrain subcortical projections

Lindsay J Agostinelli; Joel C Geerling; Thomas E Scammell

doi:10.1007/s00429-018-01820-6

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Journal article

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Peer reviewed

Basal forebrain subcortical projections

Lindsay J Agostinelli, Joel C Geerling and Thomas E Scammell

Brain structure & function, Vol.224(3), pp.1097-1117

04/2019

DOI: 10.1007/s00429-018-01820-6

PMCID: PMC6500474

PMID: 30612231

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Abstract

The basal forebrain (BF) contains at least three distinct populations of neurons (cholinergic, glutamatergic, and GABA-ergic) across its different regions (medial septum, diagonal band, magnocellular preoptic area, and substantia innominata). Much attention has focused on the BF's ascending projections to cortex, but less is known about descending projections to subcortical regions. Given the neurochemical and anatomical heterogeneity of the BF, we used conditional anterograde tracing to map the patterns of subcortical projections from multiple BF regions and neurochemical cell types using mice that express Cre recombinase only in cholinergic, glutamatergic, or GABAergic neurons. We confirmed that different BF regions innervate distinct subcortical targets, with more subcortical projections arising from neurons in the caudal and lateral BF (substantia innominata and magnocellular preoptic area). Additionally, glutamatergic and GABAergic BF neurons have distinct patterns of descending projections, while cholinergic descending projections are sparse. Considering the intensity of glutamatergic and GABAergic descending projections, the BF likely acts through subcortical targets to promote arousal, motivation, and other behaviors.

Transduction, Genetic

Vesicular Glutamate Transport Protein 2 - metabolism

Basal Forebrain - metabolism

Basal Forebrain - anatomy & histology

Mice, Transgenic

Nerve Net - physiology

Neural Pathways - physiology

Choline O-Acetyltransferase - metabolism

Neurons - classification

Animals

Vesicular Inhibitory Amino Acid Transport Proteins - metabolism

Vesicular Inhibitory Amino Acid Transport Proteins - genetics

Neurons - physiology

Brain Mapping

Female

Luminescent Proteins - genetics

Glutamic Acid - metabolism

Mice

Dynorphins - metabolism

Choline O-Acetyltransferase - genetics

Luminescent Proteins - metabolism

Vesicular Glutamate Transport Protein 2 - genetics

Details

Title: Subtitle: Basal forebrain subcortical projections
Creators: Lindsay J Agostinelli - Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
Joel C Geerling - Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA
Thomas E Scammell - Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA. tscammel@bidmc.harvard.edu
Resource Type: Journal article
Publication Details: Brain structure & function, Vol.224(3), pp.1097-1117
DOI: 10.1007/s00429-018-01820-6
PMID: 30612231
PMCID: PMC6500474
NLM abbreviation: Brain Struct Funct
ISSN: 1863-2653
eISSN: 1863-2661
Publisher: Germany
Grant note: T32 HL007901 / NHLBI NIH HHS NIH P01 HL095491-02S1 / National Institutes of Health P01 HL095491 / NHLBI NIH HHS NIH P01 HL095491 / National Institutes of Health K08 NS099425 / NINDS NIH HHS R25 NS070682 / NINDS NIH HHS
Language: English
Date published: 04/2019
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020785902771

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