Journal article
Baseline 3D Joint Space Width on Weight-Bearing CT in Comparison with 2D JSW x on Radiographs for Predicting 24-Month Worsening of Knee Structure in the Multicenter Osteoarthritis Study
Osteoarthritis imaging, 100389
12/08/2025
DOI: 10.1016/j.ostima.2025.100389
Abstract
Objective This study evaluated the predictive validity of baseline 3D joint space width (3D-JSW) measured using weight-bearing computed tomography (WBCT) versus 2D-JSW on radiographs for predicting knee structural worsening over 24 months, assessed by radiographs and MRI. DesignA prospective observational study using data from the Multicenter Osteoarthritis Study (MOST) included 425 knees. Baseline 3D-JSW was assessed using WBCT acquired in a standing fixed-flexion position, and 2D-JSW was assessed from standing fixed-flexion posteroanterior radiographs. Outcomes included 24-month changes in tibiofemoral Osteoarthritis Research Society International (OARSI) joint space narrowing (JSN) grade and MRI Osteoarthritis Knee Score Cartilage Morphology (MOAKS-CM). Predictive validity was evaluated using logistic regression and comparison of areas under ROC curves. ResultsThe study population (N=302) had a mean age of 63.2 years (standard deviation 8.9) and BMI of 28.2 kg/m² (standard deviation 4.8), with radiographic OA observed in 45.9%. For medial JSN worsening, 2D-JSW (AUC=0.711) showed significantly better predictive validity than the basic demographic model (AUC=0.626, p=0.032), while 3D-JSW (AUC=0.681) did not outperform 2D-JSW (p=0.184). For lateral JSN worsening, 3D-JSW (AUC=0.900) and 2D-JSW (AUC=0.893) were similar (p=0.814). For medial MOAKS-CM worsening, 3D-JSW (AUC=0.729) and 2D-JSW (AUC=0.742) were similar (p=0.579), as were 3D-JSW (AUC=0.699) and 2D-JSW (AUC=0.692) for lateral worsening (p=0.779). Conclusions3D-JSW did not show superior predictive validity over 2D-JSW in predicting knee structural worsening over 24 months in a cohort predominatly without radiographic knee OA. WBCT remains a promising imaging modality for osteoarthritis assessment. Further studies are needed to determine its role as a diagnostic tool.
Details
- Title: Subtitle
- Baseline 3D Joint Space Width on Weight-Bearing CT in Comparison with 2D JSW x on Radiographs for Predicting 24-Month Worsening of Knee Structure in the Multicenter Osteoarthritis Study
- Creators
- Ryo YoshikawaAli GuermaziIrina TolstykhDonald D AndersonJohn A LynchJeffrey DuryeaFrank RoemerMichael C NevittNeil A Segal
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis imaging, 100389
- DOI
- 10.1016/j.ostima.2025.100389
- ISSN
- 2772-6541
- eISSN
- 2772-6541
- Publisher
- Elsevier
- Language
- English
- Electronic publication date
- 12/08/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Orthopedics and Rehabilitation; Industrial and Systems Engineering
- Record Identifier
- 9985090592902771
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