Journal article
Baseline OCT measurements in the idiopathic intracranial hypertension treatment trial, part II: correlations and relationship to clinical features
Investigative ophthalmology & visual science, Vol.55(12), pp.8173-8179
11/04/2014
DOI: 10.1167/iovs.14-14961
PMCID: PMC4266073
PMID: 25370513
Abstract
The accepted method to evaluate and monitor papilledema, Frisén grading, uses an ordinal approach based on descriptive features. Part I showed that spectral-domain optical coherence tomography (SD-OCT) in a clinical trial setting provides reliable measurement of the effects of papilledema on the optic nerve head (ONH) and peripapillary retina, particularly if a 3-D segmentation method is used for analysis.(1) We evaluated how OCT parameters are interrelated and how they correlate with vision and other clinical features in idiopathic intracranial hypertension (IIH) patients. A total of 126 subjects in the IIH Treatment Trial (IIHTT) OCT substudy had Cirrus SD-OCT optic disc and macula scans analyzed by using a 3-D segmentation algorithm to derive retinal nerve fiber layer (RNFL) thickness, total retinal thickness (TRT), retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) thickness, and ONH volume. The SD-OCT parameter values were correlated with high- and low-contrast acuity, perimetric mean deviation, Frisén grading, and IIH features. At study entry, the average RNFL thickness, TRT, and ONH volume showed significant strong correlations (r ≥ 0.90) with each other. The same OCT parameters showed a strong (r > 0.76) correlation with Frisén grade and a mild (r > 0.24), but significant, correlation with lumbar puncture opening pressure. For all eyes at baseline, neither visual acuity (high or low contrast) nor mean deviation correlated with any OCT measure of swelling or GCL+IPL thickness. In newly diagnosed IIH, OCT demonstrated alterations of the peripapillary retina and ONH correlate with Frisén grading of papilledema. At presentation, OCT measures of papilledema, in patients with newly diagnosed IIH and mild vision loss, do not correlate with clinical features or visual dysfunction. (ClinicalTrials.gov number, NCT01003639.).
Details
- Title: Subtitle
- Baseline OCT measurements in the idiopathic intracranial hypertension treatment trial, part II: correlations and relationship to clinical features
- Creators
- Peggy AuingerMary DurbinSteven FeldonMona GarvinRandy KardonJohn KeltnerMark J KupersmithPatrick SibonyKim PlumbJui-Kai WangJohn S WernerOCT Sub-Study Committee for NORDIC Idiopathic Intracranial Hypertension Study Group
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.55(12), pp.8173-8179
- DOI
- 10.1167/iovs.14-14961
- PMID
- 25370513
- PMCID
- PMC4266073
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- U10 EY017281-01A1 / NEI NIH HHS 3U10 EY017281-01A1S1 / NEI NIH HHS U10 EY017387 / NEI NIH HHS U10 EY017281 / NEI NIH HHS U10 EY017387-01A1 / NEI NIH HHS
- Language
- English
- Date published
- 11/04/2014
- Academic Unit
- Electrical and Computer Engineering; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980084502771
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