Journal article
Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort
Journal of orthopaedic research, Vol.27(12), pp.1562-1568
12/2009
DOI: 10.1002/jor.20936
PMCID: PMC2981407
PMID: 19533741
Abstract
We studied whether contact stress estimates from knee magnetic resonance images (MRI) predict the development of incident symptomatic tibiofemoral osteoarthritis (OA) 15 months later in an at-risk cohort. This nested case-control study was conducted within a cohort of 3,026 adults, age 50 to 79 years. Thirty cases with incident symptomatic tibiofemoral OA by their 15 month follow-up visit were randomly selected and matched with 30 control subjects. Symptomatic tibiofemoral OA was defined as daily knee pain/stiffness and Kellgren-Lawrence Grade > or =2 on weight bearing, fixed-flexion radiographs. Tibiofemoral geometry was segmented on baseline knee MRI, and contact stresses were estimated using discrete element analysis. Linear mixed models for repeated measures were used to examine the association between articular contact stress and case/control status. No significant intergroup differences were found for age, sex, BMI, weight, height, or limb alignment. However, the maximum articular contact stress was 0.54 +/- 0.77 MPa (mean +/- SD) higher in incident OA cases compared to that in control knees (p = 0.0007). The interaction between case-control status and contact stress was significant above 3.20 MPa (p < 0.0001). The presence of differences in estimated contact stress 15 months prior to incidence suggests a biomechanical mechanism for symptomatic tibiofemoral OA and supports the ability to identify risk by subject-specific biomechanical modeling.
Details
- Title: Subtitle
- Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort
- Creators
- Neil A Segal - Department of Orthopaedics & Rehabilitation, The University of Iowa, Iowa City, Iowa, USA. neil-segal@uiowa.eduDonald D AndersonKrishna S IyerJennifer BakerJames C TornerJohn A LynchDavid T FelsonCora E LewisThomas D Brown
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.27(12), pp.1562-1568
- DOI
- 10.1002/jor.20936
- PMID
- 19533741
- PMCID
- PMC2981407
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K12 HD001097 / NICHD NIH HHS P50 AR055533-018768 / NIAMS NIH HHS P50 AR055533 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01 AG018832-09 / NIA NIH HHS K12HD001097-08 / NICHD NIH HHS U01 AG018947-09 / NIA NIH HHS AG18820 / NIA NIH HHS U01 AG018820-09 / NIA NIH HHS K12 HD001097-08 / NICHD NIH HHS AG19069 / NIA NIH HHS AG18947 / NIA NIH HHS AG18832 / NIA NIH HHS U01 AG019069-08S1 / NIA NIH HHS AR55533 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 12/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Epidemiology; Orthopedics and Rehabilitation; Surgery; Industrial and Systems Engineering; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995056802771
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