Baseline characteristics in the Modification of Diet in Renal Disease Study

T Greene; J J Bourgoignie; V Habwe; J W Kusek; L G Snetselaar; J M Soucie; M E Yamamoto

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Journal article

Baseline characteristics in the Modification of Diet in Renal Disease Study

T Greene, J J Bourgoignie, V Habwe, J W Kusek, L G Snetselaar, J M Soucie and M E Yamamoto

Journal of the American Society of Nephrology, Vol.4(5), pp.1221-1236

11/1993

PMID: 8305650

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Abstract

The Modification of Diet in Renal Disease Study is randomized, multicenter, clinical trial designed to determine the effects of three levels of dietary control of protein and phosphorus and two levels of blood pressure control on the rate of decline of kidney function among persons with chronic renal disease. Study participants were assigned to one of two studies, Study A or Study B, depending on their GFR just before randomization. Within each study, participants were randomly allocated to one of two levels of blood pressure control and to one of two dietary interventions according to separate 2 x 2 factorial designs. A total of 840 men and women aged 18 to 70 were randomized. This report summarizes the demographic, biochemical, and clinical characteristics of the randomized participants at the time of entry into the trail, overviews the protocol and purposes of the baseline period before randomization, and evaluates the balance among the treatment intervention groups within Studies A and B at the time of randomization. Major indicators of renal function were found to be well balanced among the treatment groups. Selected baseline characteristics of participants in the Modification of Diet in Renal Disease Study are compared with those of other renal clinical trials and with those of new cases of treated ESRD reported in the United States Renal Data System.

Blood Pressure

Kidney Failure, Chronic - physiopathology

Dietary Proteins - administration & dosage

Glomerular Filtration Rate

Anthropometry

Humans

Kidney Failure, Chronic - drug therapy

Middle Aged

Male

Kidney Failure, Chronic - diet therapy

Antihypertensive Agents - therapeutic use

Diet

Adolescent

Phosphorus, Dietary - administration & dosage

Electrocardiography

Adult

Female

Aged

Details

Title: Subtitle: Baseline characteristics in the Modification of Diet in Renal Disease Study
Creators: T Greene - Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, OH 44195-5196
J J Bourgoignie
V Habwe
J W Kusek
L G Snetselaar
J M Soucie
M E Yamamoto
Resource Type: Journal article
Publication Details: Journal of the American Society of Nephrology, Vol.4(5), pp.1221-1236
Publisher: United States
PMID: 8305650
ISSN: 1046-6673
eISSN: 1533-3450
Language: English
Date published: 11/1993
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995141802771

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