Journal article
Baseline echographic characteristics of tumors in eyes of patients enrolled in the Collaborative Ocular Melanoma Study: COMS report no. 29
Ophthalmology (Rochester, Minn.), Vol.115(8), pp.1390-1397.e2
08/2008
DOI: 10.1016/j.ophtha.2007.12.015
PMID: 18267342
Abstract
To report baseline echographic characteristics of tumors in patients enrolled in the Collaborative Ocular Melanoma Study (COMS) randomized trials, to determine how often these characteristics matched prespecified criteria for choroidal melanoma, to explore associations between echographic variables, and to compare specific echographic characteristics with pathologic characteristics of tumors in enucleated eyes.
Retrospective analyses of baseline data from multicenter randomized clinical trials.
Patients enrolled in the COMS large trial or medium tumor trials (N = 2320).
Standardized echography was used to document selected characteristics of tumors at baseline. Criteria were established to assess the consistency of echographic features with the diagnosis of melanoma. For eyes assigned to enucleation, the echographic diagnosis and evaluation for extraocular extension by the Echography Center were compared with gradings made by the Pathology Center and Pathology Review Committee.
Presence of various echographic and pathologic characteristics.
Two thousand forty-three tumors (88%) exhibited low to medium reflectivity (n = 1409), a mushroom shape (n = 101), or both (n = 533). Tumors with apical height > 10 mm were more likely (P<0.001) to have a mushroom shape and less likely to have a posterior location (P<0.001) than less elevated tumors. One thousand five hundred fifty-nine (99.7%) of 1563 tumors judged by echography to be consistent with the diagnosis of melanoma were confirmed by pathology to be choroidal melanoma. For measurable extrascleral tumors < 1.5 mm in height by pathology, the Echography Center graders judged extrascleral extension as possibly present in only 1 of 16 (6%) tumors, compared with 57% (4/7) of eyes with extrascleral extension measuring > or = 1.5 mm in height.
Eighty-eight percent of the tumors in the COMS exhibited features characteristic for melanoma: low to medium reflectivity, the classic mushroom shape, or both. Using additional preset criteria, 96% of tumors exhibited baseline echographic characteristics consistent with the diagnosis of melanoma. Echography graders were able to detect extrascleral nodules > or = 1.5 mm in elevation but not minimally elevated extraocular tumor extension. Clinicians and echographers can use these data to improve their understanding of the echographic features of untreated uveal melanomas.
Details
- Title: Subtitle
- Baseline echographic characteristics of tumors in eyes of patients enrolled in the Collaborative Ocular Melanoma Study: COMS report no. 29
- Creators
- H Culver Boldt - University of Iowa, Ophthalmology and Visual SciencesSandra Frazier ByrneMarta Marsh GilsonPaul T FingerRonald L GreenBradley R StraatsmaE Rand SimpsonBarbara S HawkinsCollaborative Ocular Melanoma Study Group
- Resource Type
- Journal article
- Publication Details
- Ophthalmology (Rochester, Minn.), Vol.115(8), pp.1390-1397.e2
- DOI
- 10.1016/j.ophtha.2007.12.015
- PMID
- 18267342
- ISSN
- 0161-6420
- eISSN
- 1549-4713
- Grant note
- EY06266 / NEI NIH HHS EY06257 / NEI NIH HHS EY06858 / NEI NIH HHS EY06280 / NEI NIH HHS EY06275 / NEI NIH HHS EY06899 / NEI NIH HHS EY06279 / NEI NIH HHS EY06288 / NEI NIH HHS EY06284 / NEI NIH HHS EY06258 / NEI NIH HHS EY06848 / NEI NIH HHS EY06276 / NEI NIH HHS EY06839 / NEI NIH HHS EY06844 / NEI NIH HHS EY06289 / NEI NIH HHS EY06253 / NEI NIH HHS EY06282 / NEI NIH HHS EY06268 / NEI NIH HHS EY06264 / NEI NIH HHS EY06291 / NEI NIH HHS EY06843 / NEI NIH HHS EY06260 / NEI NIH HHS EY06274 / NEI NIH HHS EY06283 / NEI NIH HHS EY06269 / NEI NIH HHS EY06265 / NEI NIH HHS EY06270 / NEI NIH HHS EY06287 / NEI NIH HHS EY06259 / NEI NIH HHS
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984210057202771
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