Journal article
Basics of Physics and Radiobiology for Radiopharmaceutical Therapies
Practical Radiation Oncology, Vol.12(4), pp.289-293
07/01/2022
DOI: 10.1016/j.prro.2022.04.004
PMID: 35717042
Abstract
Radiopharmaceuticals are diagnostic or therapeutic radioactive compounds typically consisting of a radionuclide, a linker/chelator, and a specific ligand for target localization. These structural components affect pharmacokinetics, biodistribution, and dosimetry, which in turn affect therapeutic efficacy and potential toxicities of any radiopharmaceutical therapy (RPT). The type of radiation emitted from the radioisotope (β+, γ, α, β-, Auger) influences whether the radiopharmaceutical can be used for imaging or therapy. Alpha emitters have higher linear energy transfer and relative biological effectiveness compared with beta emitters, as well as much shorter range. Several current RPTs have paired or surrogate positron emission tomography imaging agents, such as [68Ga] Ga-PSMA-11, [18F] DCFPyL, and [68Ga] Ga-DOTATOC/TATE. Accurate 4-dimensional dosimetry with serial single photon emission computed tomography/ computed tomography is important to consider for both tumors and normal tissues, and this has the potential to personalize therapy. Similar to external beam radiation therapy, there is a correlation between tumor dose and treatment response. RPT radiobiology differs from external beam radiation therapy in lower dose rate, longer exposure, shorter range, and more heterogeneous distribution. There are important imaging, radiation safety and regulatory considerations for RPTs requiring close collaboration with nuclear medicine, medical physics, and radiation safety.
Details
- Title: Subtitle
- Basics of Physics and Radiobiology for Radiopharmaceutical Therapies
- Creators
- Keara K. English - Johns Hopkins UniversitySusan Knox - Stanford UniversityStephen A. Graves - University of IowaAna P. Kiess - Johns Hopkins University
- Resource Type
- Journal article
- Publication Details
- Practical Radiation Oncology, Vol.12(4), pp.289-293
- Publisher
- Elsevier
- DOI
- 10.1016/j.prro.2022.04.004
- PMID
- 35717042
- ISSN
- 1879-8500
- eISSN
- 1879-8519
- Number of pages
- 5
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984383307102771
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