Journal article
Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia
Journal of virology, Vol.82(12), pp.6034-6038
06/2008
DOI: 10.1128/JVI.00100-08
PMCID: PMC2395129
PMID: 18417570
Abstract
Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, α-dystroglycan (α-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia. Lymphocytic choriomeningitis virus strains with high or low α-DG affinity and Junin virus, which binds TfR1, efficiently infected polarized epithelia only when applied to the basolateral surface or when injury compromised tight junction integrity. Viral egress from infected epithelia exhibited basolateral polarity. This study demonstrates that respiratory entry of arenaviruses occurs via basolateral receptors.
Details
- Title: Subtitle
- Basolateral Entry and Release of New and Old World Arenaviruses from Human Airway Epithelia
- Creators
- Douglas E Dylla - Genetics Ph.D. ProgramDaniel E Michele - Genetics Ph.D. ProgramKevin P Campbell - Genetics Ph.D. ProgramPaul B McCray - Genetics Ph.D. Program
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.82(12), pp.6034-6038
- DOI
- 10.1128/JVI.00100-08
- PMID
- 18417570
- PMCID
- PMC2395129
- NLM abbreviation
- J Virol
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Publisher
- American Society for Microbiology (ASM)
- Language
- English
- Date published
- 06/2008
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Internal Medicine
- Record Identifier
- 9984013922302771
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