Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning

Bess Glickman; Krista L. Wahlstrom; Jason J. Radley; Ryan T. LaLumiere

doi:10.1016/j.nlm.2024.107988

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Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning

Journal article

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Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning

Bess Glickman, Krista L. Wahlstrom, Jason J. Radley and Ryan T. LaLumiere

Neurobiology of learning and memory, Vol.215, 107988

11/2024

DOI: 10.1016/j.nlm.2024.107988

PMCID: PMC11536963

PMID: 39369810

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11536963/pdf/nihms-2029352.pdfView

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Abstract

•Basolateral amygdala (BLA) optogenetic inhibition impairs cued-response retention.•BLA-nucleus accumbens shell (NAshell) inhibition impairs cued-response retention.•BLA-NAshell inhibition impairs inhibitory avoidance (IA) retention.•BLA-NAshell inhibition does not influence spatial retention.•BLA-NAshell stimulation does not influence cued-response or IA retention. The basolateral amygdala (BLA) modulates different types of memory consolidation via distinct projections to downstream brain regions in multiple memory systems. Prior studies indicate that the BLA projects to the nucleus accumbens shell (NAshell) and that these regions interact to influence some types of behavior. Moreover, previous pharmacological work suggests the BLA and NAshell interact to influence memory. However, the precise role of the BLA-NAshell pathway has never been directly investigated in the consolidation of different types of memory including cued-response, spatial, or inhibitory avoidance (IA) learning. To address this, male and female Sprague-Dawley rats received optogenetic manipulations of the BLA or BLA-NAshell pathway immediately following training in different learning tasks. An initial experiment found that optogenetically inhibiting the BLA itself immediately after training impaired cued-response retention in a Barnes maze task in males and females, confirming earlier pharmacological work in males alone. Subsequent experiments found that BLA-NAshell pathway inhibition impaired retention of cued-response and IA learning but had no effect on retention of spatial learning. However, the present work did not observe any effects of pathway stimulation immediately after cued-response or IA learning. Together, the present findings suggest the BLA modulates the consolidation of cued-response and IA, but not spatial, memory consolidation via NAshell projections.

Basolateral amygdala

Cued-response

Inhibitory avoidance

Memory

Nucleus accumbens shell

Optogenetics

Details

Title: Subtitle: Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning
Creators: Bess Glickman - University of Iowa
Krista L. Wahlstrom - University of Iowa
Jason J. Radley - University of Iowa
Ryan T. LaLumiere - University of Iowa
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.215, 107988
DOI: 10.1016/j.nlm.2024.107988
PMID: 39369810
PMCID: PMC11536963
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: Elsevier Inc
Grant note: Na-tional Institutes of Health: MH118754, MH104384, MH132223
Declarations of interest: none. This work was supported by the Na-tional Institutes of Health grants MH118754 (KLW) , MH104384 (RTL and CKM) , and MH132223 (RTL and JJR) .
Language: English
Electronic publication date: 10/04/2024
Date published: 11/2024
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984721442202771

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